Ketamine and Kidney Injury in Cardiac Surgery

Impact of Ketamine Versus Propofol for Anesthetic Induction on Acute Kidney Injury and Renal Biomarkers in Cardiac Surgery

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05268562

Enrollment

200

Registered

2022-03-07

Start date

2022-03-02

Completion date

2027-06-01

Last updated

2026-07-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiac Surgery

Keywords

Cardiopulmonary bypass

Brief summary

The purpose of this study is to investigate the affects of ketamine use for anesthesia at the beginning of heart surgery on kidneys compared to the use of propofol.

Interventions

DRUGKetamine

1-2 mg/kg induction with additional medication administered as needed to achieve intubating conditions

DRUGPropofol

0.5-1 mg/kg induction with additional medication administered as needed to achieve intubating conditions

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

70 Years to No maximum

Healthy volunteers

Inclusion criteria

* Presenting for cardiac surgery at the Mayo Clinic in Rochester, Minnesota. * Scheduled to undergo complex cardiac surgery with the use of cardiopulmonary bypass. Complex cardiac surgery will be defined as surgery involving more than one heart valve, redo-sternotomy procedures, or combined valvular and coronary artery bypass graft procedures (aortic repair not excluded if meets other criteria).

Exclusion criteria

* Left or right ventricular assist device implantation or explantation. * Procedures not requiring cardiopulmonary bypass. * Active infection or sepsis requiring antimicrobial therapy and/or vasopressor therapy (treated endocarditis is not excluded). * Severe hepatic disease resulting in ascites. * Pre-operative significant renal dysfunction including a baseline creatinine equal to or greater than 2 mg/dL or requiring dialysis. * Immunosuppressive medication use (including current IV or oral steroids use, use of anti-rejection medications for transplant within 1 month, or chemotherapy within 6 months). * Immunodeficiency syndrome including HIV/AIDS, leukemia, and multiple myeloma

Design outcomes

Primary

Measure	Time frame	Description
Acute Kidney Injury	Immediately postop up to 10 days postoperatively	The incidence of acute kidney injury in patients following cardiac surgery

Secondary

Measure	Time frame	Description
Vasopressor use	Immediately post induction up to 30 minute following induction	Compare mean total vasopressor doses, in norepinephrine equivalents, between groups following induction as a surrogate for hemodynamic differences

Countries

United States

Contacts

PRINCIPAL_INVESTIGATORErica D Wittwer, MD, PhD

Mayo Clinic

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Jul 14, 2026