Colorectal Cancer With Liver Metastases
Conditions
Keywords
colorectal cancer with liver metastases, Radiofrequency/Microwave, Recurrence
Brief summary
This study is a retrospective, multicenter clinical study. The main objective is to analyze the risk factors affecting the recurrence of colorectal cancer patients with liver metastases who received radiofrequency/microwave ablation. Finally, we will construct a recurrence risk prediction model based on the risk factors and validated the model.
Interventions
None listed
Sponsors
Zhejiang Cancer Hospital
Zhejiang University
First Affiliated Hospital of Wenzhou Medical University
The Central Hospital of Lishui City
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Inclusion criteria
1. Age：older than 18 years； 2. Patients with a single tumor diameter ≤5cm, no more than 3 tumor nodules, and the largest tumor diameter ≤3cm； 3. Absence of vessel, bile duct and adjacent organ invasion and distant metastasis; 4. The primary tumor of colorectal cancer has been resected, the liver metastases cannot be resected or the patient is unwilling to undergo surgery (clinical or pathological confirmation); 5. Normal coagulation status and liver function child-pugh A or B; 6. Liver metastases have not received other antitumor therapy after radiofrequency/microwave therapy (before disease progression); 7. Routine laboratory tests were performed before the first RF/microwave treatment; 8. Follow up for more than 12 months; 9. Obtained free informed consent.
Exclusion criteria
1. Large tumor, or diffuse intrahepatic metastasis; 2. Accompanied by vascular tumor thrombus or invasion of adjacent organs; 3. The primary tumor of colorectal cancer has not been resected, with extrahepatic metastasis; 4. Uncorrectable coagulation dysfunction and severe blood abnormalities, those with severe bleeding tendency; 5. Intractable massive ascites, cachexia; 6. Active infection, especially inflammation of the biliary system; 7. Severe liver, kidney, heart, lung, brain and other major organ failure; 8. Patients with impaired consciousness or unable to cooperate with treatment; 9. Missing follow-up data.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The first recurrence of colorectal cancer with liver metastasis (CRLM) after radiofrequency/microwave ablation, assessed up to 18 months | Time from enrollment to disease recurrence, assessed up to 18 months | The first recurrence of colorectal cancer with liver metastasis (CRLM) after radiofrequency/microwave ablation, assessed up to 18 months |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Patients with colorectal cancer with liver metastases (CRLM) developed new metastases after radiofrequency/microwave ablation,assessed up to 18 months | Time from enrollment to developed new metastases, assessed up to 18 months | Patients with colorectal cancer with liver metastases (CRLM) developed new metastases after radiofrequency/microwave ablation,assessed up to 18 months |
Contacts
Primary ContactZhongwei Zhao, Dr
Backup ContactDengke Zhang, Dr
Outcome results
None listed