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Disconnection and Unilateral Spatial Neglect

Neural Basis of Unilateral Spatial Neglect After Stroke: a Retrospective Disconnectome Based Study

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT05268159
Acronym
DISCONEGLECT
Enrollment
300
Registered
2022-03-07
Start date
2011-06-01
Completion date
2021-12-31
Last updated
2022-05-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stroke

Keywords

Stroke, Unilateral spatial neglect, MRI, Disconnectome,, Cognition

Brief summary

Retrospective cohort study of consecutive patients investigated in a neurorehabilitation ward after a first hemispheric stroke. Unilateral spatial Neglect (USN) and other cognitive impairments (including attention, executive functions, memory) have been assessed in routine care at the subacute phase (\<6 months). MRI scans have also been done in routine care. The study aims at linking lesion characteristics, disconnections induced and expression of the different modalities of USN

Interventions

OTHERCognitive assessment

Assessment of unilateral spatial neglect, attention, executive functions and memory

Sponsors

University Hospital, Lille
Lead SponsorOTHER

Study design

Observational model
CASE_ONLY
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* First hemispheric adult stroke patient * Non-opposed to inclusion * Confirmed by MRI * Assessment of cognitive functions during the subacute phase (3 weeks to 6 months after stroke onset

Exclusion criteria

* History of previous stroke or neurological disorders * Inability to perform cognitive assessment due to severe comprehension, cognitive or psychiatric disorder * Uncorrected severe loss of visual acuity * Contra-indications to MRI

Design outcomes

Primary

MeasureTime frame
Assessment of peripersonal Unilateral Neglect with the BEN (Batterie d'évaluation de la negligence, Battery of tests for the quantitative assessment of unilateral neglect)One assessment, during the subacute phase after stroke (3 weeks to 6 months)

Secondary

MeasureTime frame
Assessment of personal Unilateral Spatial Neglect with the Comb and Razor TestOne assessment, during the subacute phase after stroke (3 weeks to 6 months)
Assessment of Attention with the Test of Attentional PerformanceOne assessment, during the subacute phase after stroke (3 weeks to 6 months)
Assessment of Executive Functions with the Stroop TestOne assessment, during the subacute phase after stroke (3 weeks to 6 months)
Assessment of Executive Functions with the Trail Making TestOne assessment, during the subacute phase after stroke (3 weeks to 6 months)
Assessment of Executive Function with Verbal and Categorial Fluency testOne assessment, during the subacute phase after stroke (3 weeks to 6 months)
Assessment of Executive Functions with the test of commissionsOne assessment, during the subacute phase after stroke (3 weeks to 6 months)
Assessment of personal Unilateral Spatial Neglect with the Fluff TestOne assessment, during the subacute phase after stroke (3 weeks to 6 months)
Assessment of verbal Memory with the Grober and Buschke TaskOne assessment, during the subacute phase after stroke (3 weeks to 6 months)
Assessment of visual Memory with the Doors testOne assessment, during the subacute phase after stroke (3 weeks to 6 months)
Assessment of visual Memory with the Rey figure testOne assessment, during the subacute phase after stroke (3 weeks to 6 months)
Identification of brain lesions by Anatomical MRI (T1, FLAIR, T2*, Diffusion)up to 6 months
Postural assessment with the PASS1 month after stroke
Gait assessment (Lindmark score)1 month after stroke
Assessment of verbal Memory with the verbal span taskOne assessment, during the subacute phase after stroke (3 weeks to 6 months)

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026