Recurrent Miscarriage
Conditions
Brief summary
This prospective cohort study primarily aims to examine the association between blood niacin levels and recurrent miscarriage.
Detailed description
Recurrent miscarriage is affecting around 5% women at reproductive age. And the underlying causes remain undetermined in 50%-70% of cases. Although animal models and linkage analysis according to family studies have identified that niacin deficiency can lead to congenital malformations and recurrent miscarriage. Evidence based on population is lacking with regard to the effect of blood niacin levels on recurrent miscarriage. We intend to enroll 499 pregnant women confirmed by a positive blood human chorionic gonadotropin test and with history of unexplained recurrent miscarriage. By testing their blood niacin levels and following up to the end of first-trimester pregnancy, this study aims to examine the role of niacin levels in preventing miscarriages among women with history of recurrent miscarriage.
Interventions
OTHERNo intervention
This is an observational study without any intervention
Sponsors
Peking Union Medical College Hospital
Westlake University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* 18-40years old, female * Positive blood human chorionic gonadotropin test * Naturally pregnant * History of recurrent miscarriage (2 or more consecutive spontaneous miscarriage within 28 weeks of gestation) * Willing to participate in this study with informed consent
Exclusion criteria
* Women whose confirmed cause of recurrent miscarriage has nothing to do with nutritional deficiencies, including chromosomal abnormalities, abnormal uterine anatomy, immune system diseases, blood diseases, etc. * Women with Hepatitis B, syphilis, HIV/AIDS and other infectious diseases. * Women with serious conditions, such as schizophrenia, tumors, heart failure
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of participants with miscarriage | 6-13(+6) weeks of gestation | pregnancy outcomes are confirmed by electronic hospital records or self-reported by participants |
| Gestation week at miscarriage | 6-13(+6) weeks of gestation | pregnancy outcomes are confirmed by electronic hospital records or self-reported by participants |
Countries
China
Contacts
Primary ContactHongjun Shi, PhD
Backup ContactDanyang WANG, MPH
Outcome results
None listed