Glioma, Malignant
Conditions
Brief summary
The most aggressive primary brain tumors in adults, glioblastomas, are characterized by a profound local and systemic immune suppression. During tumor progression, the infiltration of inflammatory leukocytes, especially of myeloid origin, endowed with immunosuppressive function is observed. Aim of this study is to evaluate myeloid cell infiltrate and iron metabolism in tumor-associated macrophages by combining a multimodal MRI imaging technique with immunophenotyping of the tumor microenvironment.
Interventions
None listed
Sponsors
Istituto Oncologico Veneto IRCCS
Azienda Ospedaliero-Universitaria Careggi
Azienda Ospedaliera di Padova
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* All patients with histologic confirmation of malignant glioma * Patients must be age \>= 18 years * Patients must be able to obtain an MRI scan with gadolinium contrast * Patients must sign informed consent indicating that they are aware of the investigational nature of this study:
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Evaluate leukocyte/myeloid cell-infiltrate in gliomas by using a multimodal PET/MRI imaging technique | 24 months | apply iron-sensitive MRI sequences in glioma patients to identify macrophage iron deposits as biomarker of in vivo immune suppression, and correlate these findings with 5-Ala intraoperative data and analysis of MG and BMDM infiltration. |
Countries
Italy
Contacts
PRINCIPAL_INVESTIGATORSusanna Mandruzzato, PhD
Istituto Oncologico Veneto IOV-IRCCS
Outcome results
None listed