Antioxidative Stress, End Stage Renal Disease on Dialysis
Conditions
Keywords
Oxidative stress, Antioxidants, mitochondrial function, CoQ10, miRNA-126, Hemodialysis
Brief summary
An Open labeled, Paralled, Randomized, Prospective, study was conducted on 60 patients who were randomized into 3 groups, 22, 20 and 18 patients in Control, Selenium and, Thiotacid groups respectively. Serum levels of ROS, CoQ10, and miRNA-126 were assessed at base line and after three months for all patients.
Interventions
DRUGAlpha lipoic acid
20 patients who received Alpha Lipoic acid (ALA) (Thiotex fort®) 600mg once daily with their routine therapy just after the dialysis sessions for 3 months.
DRUGSelenium
23 patients who received Selenium 200µg once daily with their routine therapy just a
Sponsors
Ain Shams University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* prevalent hemodialysis patients
Exclusion criteria
* Patients with Inflammatory diseases, hepatic or respiratory diseases, smokers and alcoholics, were excluded from the study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in miRNA-126 level | 3 months | Fold expression |
| Change ROS level (ng/ml) | 3 months | Using ELISA kit |
| Change in Co Q10 level (ng/ml) | 3 months | Using ELISA kit |
Countries
Egypt
Outcome results
None listed