Atrial Fibrillation, Atrial Fibrillation Recurrent
Conditions
Brief summary
This is a single-center prospective observational cohort study of atrial fibrillation patients treated with radiofrequency ablation.
Detailed description
The effect of radiofrequency therapy on the life quality and atrial function of atrial fibrillation patients will be assessed, through the multidimensional analysis of baseline clinical data, serological indicators of atrial fibrosis, echocardiography, cardiac magnetic resonance imaging, atrial potential mapping, life quality, and long-term ECG monitoring within 1 week after radiofrequency ablation. A predictive model for atrial fibrillation recurrence after ablation will be established. Based on the cross-sectional analysis of baseline data, the relationship between non-invasive assessment of atrial fibrosis (imaging and serology), atrial electrical activity, and atrial function will be analyzed as well, and atrial fibrillation patients with ventricular fibrosis will be selected for gene sequencing to explore the existence of underlying cardiomyopathy and provide data for further research.
Interventions
PROCEDUREradiofrequency ablation
Bilateral pulmonary vein isolation, a kind of radiofrequency ablation, is performed in atrial fibrillation patients for atrial arrhythmia therapy.
Sponsors
Peking Union Medical College Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Non-valvular atrial fibrillation, including paroxysmal atrial fibrillation and persistent atrial fibrillation * 18-80 years old * The anteroposterior diameter of the left atrium is less than 50mm via TTE * Patient meets the intervention criteria for bilateral pulmonary vein isolation after evaluation by electrophysiological specialists * Patient consents to ablation treatment
Exclusion criteria
* Intra-atrial thrombus detected by TEE * Hyperthyroidism * Previous radiofrequency ablation for atrial fibrillation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Recurrence assessed by ECG, Holter reports and outpatient physicians | at 1-year follow-up after ablation | Recurrence includes atrial fibrillation and atrial flutter. Recurrence features including pattern, duration, burden, etc. will be recorded. |
| All-cause mortality assessed by telephone follow-up or medical records | at 1-year follow-up after ablation | Time and cause of death will be recorded. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Improvement in life quality assessed by QOLSF36 Questionnaire | at 1-year follow-up after ablation | Life quality will be assessed at baseline and 1-year FU. Improvement in life quality indicates that patients can benefit from the catheter ablation. |
| Improvement in left atrial function assessed by echocardiography | at 1-year follow-up after ablation | Left atrial function will be assessed at baseline and 1-year FU. Improvement in atrial function indicates that ablation can restore atrial function. |
| Embolic events assessed by physicians and further examinations like ultrasound, MRI | at 1-year follow-up after ablation | Embolism may be related to atrial fibrillation. Embolism will be assessed by physicians according to patients' symptoms and signs at clinic or by telephone. If a patient's clinical presentation indicates embolism, the patient will be further assessed by ultrasound, MRI, etc. |
| Hospitalization for heart failure, atrial fibrillation or atrial flutter | at 1-year follow-up after ablation | Postoperative hospitalization indicate worse prognosis. |
Countries
China
Contacts
Primary ContactYongtai Liu, M.D.
Outcome results
None listed