Prosthetic-joint Infection
Conditions
Keywords
debridement, antibiotics and implant retention (DAIR), sonication fluid analysis
Brief summary
This retrospective study is to analyse microbiological cultures from the sonication fluid of the explanted prothesis to detect bacteria in the biofilm on the implant surface and to investigate whether the number of bacteria in the biofilm correlates with the duration of the PJI respectively with the period between symptom onset and date of revision surgery.
Detailed description
Implant associated infections in orthopaedics and trauma surgery are a well-known and feared complication. Prosthetic-joint infection (PJI) is caused by a biofilm which is located atop the surface of the implant which as growing with the duration of the PJI. This retrospective study is to analyse microbiological cultures from the sonication fluid of the explanted prothesis to detect bacteria in the biofilm on the implant surface and to investigate whether the number of bacteria in the biofilm correlates with the duration of the PJI respectively with the period between symptom onset and date of revision surgery.
Interventions
None listed
Sponsors
University Hospital, Basel, Switzerland
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* patients who underwent a revision surgery of hip, knee and shoulder arthroplasties operated at the university hospital of Basel between 2011 and 2021, * patients who had a PJI as a suspected diagnosis and * have microbiological cultures from sonication fluid from removed prosthesis.
Exclusion criteria
* patients in the database who 1. have non-bacterial microbiological positive cultures (e.g. fungal infection) and 2. have not received a sonication of the removed prosthesis during the diagnostic process
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| number of bacteria | one time assessment at baseline | number of bacteria detected during revision surgery will be taken from the sonication fluid and the quantitative analysis of the microbiological samples |
| duration of the infection | one time assessment at baseline | duration of the infection |
Countries
Switzerland
Outcome results
None listed