BRCA1 Gene Mutation, BRCA2 Gene Mutation
Conditions
Brief summary
This trial studies how well a video-based intervention works in helping participants encourage their families to get tested for BRCA gene mutations. Testing in families with BRCA gene mutations can allow for risk management and reduction with the overall goal of reducing cancer burden. Video-based intervention sent via text messages may help participants easily share information about BRCA gene mutations with family members.
Detailed description
PRIMARY OBJECTIVES: I. To understand whether the use of a video-based message to encourage cascade testing, delivered via short message service (SMS) (text message) or shared on social media, is superior to a written message as a method of information-sharing among families that have BRCA gene mutations. OUTLINE: Participants are randomized to 1 of 2 arms. ARM A: Participants receive a 2-minute information-graphic video via text message consisting of misconceptions and issues that may be paramount when discussing mutation status with relatives that they can share with family via text message, email, or social media. ARM B: Participants receive family letter via U.S. postal service mail consisting of misconceptions and issues that may be paramount when discussing mutation status with relatives.
Interventions
OTHERInformational Intervention
Receive information-graphic video
OTHERSurvey Administration
Ancillary studies
Sponsors
Ohio State University Comprehensive Cancer Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Individuals who test positive for mutations in BRCA1 or BRCA2 are eligible for this study * Family members who receive the video message/family letter will be invited to participate
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Impact of a web-based video delivered via text message or shared on social media on information sharing among relatives belonging to families with BRCA gene mutations | Up to 3 years | Measure participant-reported information sharing among family members prior to receipt of the video and after the video. There is no previously validated scale/set of items for this. Items are investigator created and assess likelihood to share information with family members on a Likert scale. |
| Impact of participant-reported family dynamics on information sharing | Up to 3 years | Brief family relationship scale will be used to determine whether differences in family dynamics could be associated with differences in family sharing. A higher score for the cohesion and expressiveness subscales generally indicates more positive dynamics and a the conflict subscale is inversely scored. |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORLeigha Senter, LGC
Ohio State University Comprehensive Cancer Center
Outcome results
None listed