Cardiac Arrest
Conditions
Brief summary
This will be a single center, retrospective, before-and-after, chart review of all patients undergoing TTM between June 1, 2017 and May 31, 2021 at MDMC. Initiation of the new TTM protocol occurred on April 22, 2019.
Detailed description
This will be a single center, retrospective, before-and-after, chart review of all patients undergoing TTM between June 1, 2017 and May 31, 2021 at MDMC. Initiation of the new TTM protocol occurred on April 22, 2019. To allow for an adequate washout period, patients who were initiated on TTM before April 22, 2019 will be in the "before" group and patients initiated on TTM on or after June 1, 2019 will be in the "after" group. Patients will be identified based on electronic medical records search of order sets utilized in TTM and confirmed with manual chart review. Statistical analysis will be performed as detailed below.
Interventions
None listed
Sponsors
Methodist Health System
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age \> 18 years * Diagnosis of cardiac arrest * Initiation of TTM via Arctic Sun® device
Exclusion criteria
* Initiation of TTM \> 12 hours after cardiac arrest * Receiving NMBs for an indication other than TTM * Early termination of TTM (less than 24 hours)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| NMB usage | June 1, 2017 - May 31, 2021 | vecuronium or cisatracurium |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| NMB usage | June 1, 2017 - May 31, 2021 | Proportion of patients that required any vecuronium boluses Number of vecuronium boluses administered Proportion of patients that required initiation of cisatracurium infusion |
| Patients discharged home | June 1, 2017 - May 31, 2021 | Proportion of patients discharged home |
| Patients with a breakthrough fever (temperature > 38°C) in the first 72 hours of TTM initiation | First 72 hours of TTM initiation | Proportion of patients with a breakthrough fever (temperature \> 38°C) in the first 72 hours of TTM initiation |
| Proportion of patients cooled to 33°C versus 36°C | June 1, 2017 - May 31, 2021 | number of patients at desired temperature range |
| Time to target temperature from initiation of TTM | June 1, 2017 - May 31, 2021 | time in minutes |
| ICU length of stay | June 1, 2017 - May 31, 2021 | number of days |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORTamara Reiter, PharmD
Methodist
Outcome results
None listed