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Exercise Testing in Diseases and Health

Cardio Pulmonary Exercise Testing (CPET) in Diseases and Health

Status
UNKNOWN
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT05263687
Enrollment
1000
Registered
2022-03-02
Start date
2017-08-30
Completion date
2025-12-30
Last updated
2022-03-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Exercise Test

Brief summary

Cardiopulmonary exercise test (CPET) is a helpful tool for evaluation of aerobic exercise capacity and tolerance for variety of population. CPET provides a full assessment of the physiologic responses of the pulmonary, cardiovascular, muscular, and cellular oxidative systems to exercise. The test progression include a incremental stepwise (on treadmill) or ramp control protocol (on bike ergometer ) to exhaustion. Measurement of respiratory gas exchange i.e. oxygen uptake, carbon dioxide, minute ventilation, other variables while monitoring ECG, blood pressure, pulse oximetry and exertion perceived (Borg Scale) during an incremental test . Aim: To compere exercise responses for maximal exercise testing with different population.

Detailed description

Each participants will conducted an exercise test on treadmill using Modified Bruce Protocol) or cycle ergometer. Quark CPET metabolic cart (Cosmed, Rome, Italy) will be use to collect and analysis gas exchange. 10 minute after the graded exercise test Supra maximal exercise test (SMT) will be done for 2 minutes one stage (treadmill protocol) or 10% at cycle protocol higher than highest load achieved in the incremental test. all outcome measurement will be collected. Exercise tolerance and responses will be assess using the data of : pulmonary gas exchange; cardiovascular performance, and skeletal muscle metabolism.

Interventions

DIAGNOSTIC_TESTMaximal exercise test

Each participants will conduct a spirometry test and exercise test on treadmill (using Modified Bruce Protocol) or cycle ergometer. Quark CPET metabolic cart (Cosmed, Rome, Italy) will be used to collect and analysis gas exchange, ECG, gas volume in addition rating of perceived exertion will be asked.

Sponsors

The Baruch Padeh Medical Center, Poriya
Lead SponsorOTHER_GOV

Study design

Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
4 Years to 80 Years
Healthy volunteers
Yes

Inclusion criteria

\*Patient who invited to the clinic to do incremental maximal exercise test or healthy \*Participants with no known significant health problems.

Exclusion criteria

* Acute fever * Acute myocardial infarction within 2 to 3 days. * Unstable angina not previously stabilized by medical therapy. * Uncontrolled cardiac arrhythmias causing symptoms or hemodynamic compromise. * Symptomatic severe aortic stenosis. * Uncontrolled symptomatic heart failure. * Inability to perform exercise Orthopedic impairment severely compromising exercise performance.

Design outcomes

Primary

MeasureTime frameDescription
Maximal Oxygen consumptionthrough study completion, an average of 1 yearthe maximum amount of oxygen that an individual can utilize during intense or maximal exercise.
Maximal Heart ratethrough study completion, an average of 1 yearthe maximum heart rate achieved during intense or maximal exercise.
Maximal Blood pressurethrough study completion, an average of 1 yearthe blood pressure in the end of intense or maximal exercise.

Secondary

MeasureTime frameDescription
Ventilation Anaerobic Thresholdthrough study completion, an average of 1 yearVentilatory Threshold (VT) describes the inflection point for ventilation during an incremental exercise test.

Countries

Israel

Contacts

Primary ContactGur Mainzer, MD
GMainzer@poria.health.gov.il+972543078940
Backup ContactEinat Kodesh, PhD
Ekodesh@poria.health.gov.il+972523489854

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026