Endometrial Cancer, LVSI
Conditions
Brief summary
We retrospectively analyzed data and compared the impact of intrauterine manipulators on incidence of LVSI in endometrial cancer patients treated at our department.
Detailed description
Endometrial cancers are among the epithelial malignancies of the lining in the uterine cavity. Standard treatment is surgical, which includes a hysterectomy. The invasion of carcinoma into the lymphovascular space (LVSI - lymphovascular space invasion) is considered a risk factor for the course of the disease Based on the recommended procedures of ESGO-ESTRO-ESP (2020) in the management of endometrial cancer, in the event of significant LVSI positivity, the female patients are included in the upper-medium risk group. A confirmation of LVSI in the preparation is of diagnostic, therapeutic and theoretical importance. During endoscopy approach, we use two types of uterine manipulators, namely the Koh-RUMI manipulator (Cooper Surgical) and the Hegar dilatator along with the McCartney tube (LiNA Medical). We analyzed data and compared the impact of intrauterine manipulators on the incidence of LVSI. In addition, we analyzed tumor grading, invasion and primary histology obtaining methods - curettage or hysteroscopy in correlation to incidence of LVSI.
Interventions
PROCEDUREhysterectomy
Hysterectomy as primary surgical treatment of endometrial cancer. Abdominal laparotomy approach was performed without intrauterine manipulator (NonManip). Endoscopic - total laparoscopic hysterectomy, laparoscopic assisted vaginal hysterectomy or robotic hysterectomy was performed with use of intrauterine manipulator (Manip). It was Hegar dilatator (ManipHe) or Koh-Rumi device (ManipKoRu).
Sponsors
F.D. Roosevelt Teaching Hospital with Policlinic Banska Bystrica
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Healthy volunteers
No
Inclusion criteria
* endometrioid endometrial cancer, * planned primary surgical treatment - hysterectomy, * medical condition enabling anesthesia and surgery, * pre-surgical clinically-determined affecting of the uterine according to MRI or ultrasound - cT1a or cT1b
Exclusion criteria
* non-endometrioid type of tumor in definitive histology, * stage 2 of a disease and higher, * previous chemo or radiotherapy, * inability to adequately complete the surgery, * uterine perforation during surgery
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| LVSI and intrauterine manipulator | oct. 2015 - jan. 2021 | Finding of the difference in the incidence of LVSI in female patients with and without an intrauterine manipulator |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| LVSI and type of intrauterine manipulator | oct. 2015 - jan. 2021 | The effect of a type of an intrauterine manipulator on the incidence of LVSI |
Other
| Measure | Time frame | Description |
|---|---|---|
| LVSI and grading of tumor | oct. 2015 - jan. 2021 | Connection between grading of tumor and incidence of LVSI |
| LVSI and myometrial invasion | oct. 2015 - jan. 2021 | Connection between myometrial invasion of tumor and incidence of LVSI |
| LVSI and primary histology procedure | oct. 2015 - jan. 2021 | Method of obtaining primary histology, hysteroscopy or curettage in connection to incidence of LVSI. |
Countries
Slovakia
Outcome results
None listed