Digestive Cancer, Gastric Cancer, Gastric Neoplasm, Laparoscopic, Surgery
Conditions
Brief summary
Immunonutrition (IN) appears to reduce infective complications and in-hospital length of stay (LOS) after gastrointestinal surgery. More specifically, it seems to be beneficial also in gastric cancer surgery. Potential benefits of combining preoperative IN (PIN) with protocols of enhanced recovery after surgery (ERAS) in reducing LOS in laparoscopic total gastrectomy are yet to be determined.
Interventions
DIETARY_SUPPLEMENTimmunonutrition
nutridrinks 3 times a day 5 days prior surgery plus maltodextrins the day of surgery
Sponsors
University of Rome Tor Vergata
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Inclusion criteria
* Age \>18 years * Primary gastric cancer * Preoperative staging I-III * Eligible for laparoscopic D2 total gastrectomy
Exclusion criteria
* Acquired or congenital immunodeficiency * Malnutrition (MNA-SF score \< 12) * Preoperative infection * Previous gastric surgery * ASA IV * Emergency setting * Para-aortic node involvement * Intraoperative evidence of distant metastasis or peritoneal carcinosis * Conversion to open surgery
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| 30-days postoperative complications | up to 30 days after discharge | Rate of any complication after colorectal resection |
| LOS | up to 30 days after discharge | number of days between primary colorectal resection and discharge |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Ileus | up to 30 days after discharge | rate of any ileus clinically demonstrated |
| Prolonged length of stay | up to 30 days after discharge | rate of any patient discharged after 15 days |
| Readmission | up to 30 days after discharge | Rate of any unplanned readmission after discharge |
| Anastomotic leak | up to 30 days after discharge | rate of any postoperative leakage of oesophagojejunal, jejunojejunal anastomosis, clinically, radiologically or endoscopically demonstrated |
| Time of first defacation | up to 30 days after discharge | time to first bowel opened to stool |
| Time of tolerated fluid intake | up to 30 days after discharge | time to first tolerated fluid intake |
| Time of tolerated food intake | up to 30 days after discharge | time to first tolerated food intake |
| Mortality | up to 30 days after discharge | Rate of any mortality |
| Pneumonia | up to 30 days after discharge | rate of radiologically demonstrated pneumonia |
Outcome results
None listed