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Title: Comparison of Anti-plaque Efficacy of Natural Honey With Chlorhexidine Mouthwash: A Randomized Controlled Trial

Comparison of Anti-plaque Efficacy of Natural Honey With Chlorhexidine Mouthwash: A Randomized Controlled Trial

Status
Completed
Phases
Phase 1
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT05258955
Enrollment
60
Registered
2022-02-28
Start date
2020-06-03
Completion date
2021-01-21
Last updated
2022-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dental Plaque

Keywords

Dental plaque, Honey, Chlorhexidine

Brief summary

The rationale of our study is to compare the efficacy of natural honey base preparation with other commercially available mouthwashes i.e chlorhexidine base in prevention of dental plaque formation as honey is readily available and cost effective and organic in nature. This study will help to provide the data of our community and positive result may provide a new method of oral hygiene maintenance with fewer side effects. We will be able to deliver the best anti-plaque agent.

Detailed description

In this study, participants will assigned into 2 group those who will fulfilled the inclusion and exclusion criteria. After the informed consent, they were divided into 2 group. Group A will received Chlorhexidine mouthwash and Group B will provided with honey based mouthwash. The participant will blinded as solution will be provided in dark color bottle to mask the study. After which the baseline plaque index will be taken followed by recording plaque index on 7th, 14th, and 21st day. The statistical analysis will be done to compare the mean difference between these 2 groups

Interventions

Natural Sidr honey based mouthwash used as intervention group B (Arm Group B) for the reduction of plaque index

DRUGChlorhexidine mouthwash

Chlorhexidine gluconate 0.12% mouthwash is used as intervention in Group A (Arm Group A) for the comparison of plaque reduction among group A and B

Sponsors

Liaquat College of Medicine and Dentistry
CollaboratorOTHER
Liaquat National Hospital & Medical College
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)

Masking description

The mouthwash were distributed in dark color coded bottle and marked with label A and B, as to maintain masking among the the participants of the study.

Intervention model description

The participants divided into two groups. one group will received honey based oral rinses and other group received chlorhexidine mouthwash and will evaluate the reduction of dental plaque

Eligibility

Sex/Gender
ALL
Age
18 Years to 25 Years
Healthy volunteers
Yes

Inclusion criteria

1. Individual aged between 18-25 2. Retained 28 number of teeth excluding wisdom teeth

Exclusion criteria

1. Individual with medical illness affecting oral cavity like diabetes, sjögren syndrome, crohn disease etc 2. Multiple extraction , overhang restoration, wearing any appliance 3. Periodontal problem with pocket depth more than 3mm 4. Current or recent history of antibiotic consumption 5. Noncompliance that is unable to maintain their hygiene. 6. Pan, Betel quid and any other oral habit will not be included in study

Design outcomes

Primary

MeasureTime frameDescription
Dental Plaquereduction of plaque index will be assessed on 7th day, 14th day and on 21st dayprimary outcome is to assessed the reduction on plaque level among Group A and Group B

Countries

Pakistan

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026