Osteogenesis Imperfecta, Tooth Socket, Total Absence of Permanent Teeth
Conditions
Brief summary
This study is mainly targeted affected teeth which could not be retained, and patients are willing to undergo implant repair at the later stage. After teeth extraction, Geistlich Bio-Oss ® Particles or Bio-Oss ® Collagen are immediately implanted in the teeth extraction socket and covered with Bio-Gide ® collagen membrane for site preservation.Through postoperative follow-up, postoperative clinical and imaging objective indicators, combined with the subjective evaluation of surgeons and patients, and compared with conventional extraction treatment method, the study is aimed to evaluate the effectiveness of different site preservation of alveolar crest preservation, in order to reduce the alveolar bone width and height loss, effectively reduce alveolar bone absorption, or even achieve bone incrementation, thus to get the ideal site preservation effect, to improve the oral implant success rate, improve implant aesthetic score and patient satisfaction, provide more clinical standard reference of the clinical application of site preservation.
Interventions
None listed
Sponsors
Nanfang Hospital, Southern Medical University
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* patients willing to performed site preservation with Geistlich Bio-Oss ® Particles + Bio-Gide ® collagen membrane after tooth extraction; * patients willing to performed site preservation with Geistlich Bio-Oss ® Collagen + Bio-Gide ® collagen membrane after tooth extraction; * patients willing to performed no site preservation after tooth extraction and only conventional healing.
Exclusion criteria
* patients unwilling to sign the informed consent form and the letter of authorization; * patients has a potential systematic diseases; * patients had previously been treated with radiation therapy; * patients can not re-visit on time.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in the alveolar crest height - central | up to 12 weeks after Dental extraction or site preservation surgery | The central alveolar bone height of the ideal implant site will be measured with CBCT at 3 months after tooth extraction or plus site preservation |
| Changes in the alveolar crest width - central | up to 12 weeks after Dental extraction or site preservation surgery | The central alveolar bone width of the ideal implant site will be measured with CBCT at 3 months after tooth extraction alone or plus site preservation |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Soft tissue thickness | up to 12 weeks after Dental extraction or site preservation surgery | The thickness of soft tissue will be measured at middle, central, and distal sites of both buccal-lingual sides,3mm from free gingival margin |
| Plaque index (PLI) | up to 12 weeks after Dental extraction or site preservation surgery | Each tooth extraction socket will be measured on 6 sites: buccal, central and lingual of both mesial-distal sides |
| Bleeding index (BI) | up to 12 weeks after Dental extraction or site preservation surgery | Each tooth extraction socket will be measured on 6 sites: buccal, central and lingual of both mesial-distal sides |
| Changes in the alveolar bone width - different depths | up to 12 weeks after Dental extraction or site preservation surgery | The width of the alveolar bone at 1,3,5, and 7mm below the alveolar crest will be measured with CBCT at 3 months after tooth extraction or plus site preservation |
| Phenotype assessment | up to 12 weeks after Dental extraction or site preservation surgery | Whether thick or thin gingival biotype will be detected by the transparency of the soft tissue while periodontal probing diagnosis |
| Pain degree | up to 12 weeks after Dental extraction or site preservation surgery. | The Visual Analogue Scale (VAS) pain score was evaluated: 0-10 (0: no pain; 1-3: slightly painful, acceptable; 4-6: painful, disrupt sleep, tolerable; 7-10: very painful, untolerable, affect sleep and diet) |
| Probing depth (PD) | up to 12 weeks after Dental extraction or site preservation surgery | Each tooth extraction socket will be measured on 6 sites: buccal, central and lingual of both mesial-distal sides |
| Changes in the alveolar bone height - different horizontal sites | up to 12 weeks after Dental extraction or site preservation surgery | The height of the alveolar bone will be measured at the mesial, central and distal of buccal and lingual of alveolar crest,and the midpoint of the mesial and distal of interproximal sites with CBCT at 3 months after tooth extraction alone or plus site preservation |
Contacts
Primary ContactQi Liu, Ph.D.
Outcome results
None listed