Periodontitis (Stage 3)
Conditions
Brief summary
The aim of the present study was to evaluate the effect of demineralized autogenous dentine on treatment of infrabony defects.
Detailed description
In this study, the investigators tested the effect of demineralized autogenous dentine as a bone graft in treatment of stage III periodontitis in term of probing pocket depth reduction, mean gain in clinical attachment level, and bone gain in defect sites.
Interventions
PROCEDUREAutogenous demineralized dentin nanoparticles
Effect of Autogenous demineralized dentin nanoparticles in bone gain in infrabony defect
Sponsors
October 6 University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
16 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
* Patients with good systemic health and no contraindication for periodontal surgery. * Patients who are able to maintain good oral hygiene. * Gingival thickness for the site selected should be ≥1mm. * Probing depth of ≥ 6mm. * Patient has at least one hopeless teeth
Exclusion criteria
* Active infectious diseases (hepatitis, tubercu¬losis, HIV, etc….). * Medically compromised patients. * Smokers and alcoholic abusers * People who suffer from any systemic disease that affect the periodontium. * Pregnant, postmenopausal women. * People who take anti-inflammatory drugs, anti¬biotics or vitamins within the previous 3 month. * People who use mouth washes regularly * Participants in other clinical trials.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Vertical bone loss | 6 months | vertical bone loss was measured from cementoenamel junction (CEJ) to the base of the bone defect in each site in group I & II. |
| Clinical attachment level | 6 months | Clinical attachment level was measured at baseline and 6 months |
| Probing pocket depth | 6 months | Probing pocket depth was measured at baseline and 6 months |
| Bone gain | 6 months | The bone gain is calculated by: * Preoperative VBL (at baseline): measured as the distance from cementoenamel junction (CEJ) to the base of the bone defect. * Postoperative VBL (after 6 months) measured as the distance from cementoenamel junction (CEJ) to the base of the bone formation. * Postoperative bone fill (bone gain after 6 months) \[measured by subtracting the preoperative VBL from the postoperative VBL\]. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Plaque Index | 6 months | plaque index was measured at baseline, 3, 6 months |
| Gingival index | 6 months | Gingival index was measured at baseline, 3, 6 months |
Countries
Egypt
Outcome results
None listed