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Intradialytic High-Intensity Interval Training in Hemodialysis Patients

The Effect of Intradialytic High-Intensity Interval Training and Moderate Intensity Training on Dialysis Adequacy and Functional Capacity in Hemodialysis Patients

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT05257668
Enrollment
69
Registered
2022-02-25
Start date
2021-10-18
Completion date
2022-07-30
Last updated
2023-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

End Stage Renal Disease, Exercise, Compulsive

Keywords

intradialytic exercise, high-intensity interval training, chronic kidney disease, dialysis adequacy, functional capacity

Brief summary

Chronic Kidney Disease (CKD) is defined as a chronic, progressive degeneration state in the regulation of the fluid-electrolyte balance of the kidney and metabolic-endocrine functions as a result of the glomerular filtration rate (GFR) falling below 60 ml/min/1.73 m², regardless of the etiology of the kidney disease. End Stage Renal Failure (ESRD) is the last stage of CRF and is a life-threatening condition. Although the majority of ESRD patients survive on dialysis, their quality of life and functional capacity decrease due to uremic cardiomyopathy, cardiovascular diseases, anemia, diabetes mellitus, bone diseases, deconditioning, fatigue, weakness, inactivity and accompanying psychological problems. Rehabilitation program including exercise in CKD patients; The program, which is performed under observation on non-dialysis days, can be applied in three ways: the (intradialytic) rehabilitation program performed during hemodialysis in the dialysis unit, and the home exercise program. Intradialytic exercise (IDE) is defined as exercise training performed during the hemodialysis session to increase the patient's strength and endurance and thus target various physiological and psychosocial parameters. Three types of exercises are generally recommended in the exercise program for dialysis patients. These are aerobic exercise, strengthening exercise, and combined aerobic and resistance exercise program. Aerobic exercise (both on dialysis and on non-dialysis days) is the most common type of exercise used in hemodialysis patients. It is stated that physical exercise improves the exercise capacity, muscle strength, functional capacity and quality of life of patients receiving dialysis treatment, provides blood pressure control, reduces the risk of diabetes development and cardiovascular disease, alleviates depression and anxiety symptoms, increases survival and dialysis efficiency. When the literature is examined, no study has been found that examines how the application of high-intensity intermittent exercise training, which has very important advantages, in the intradialytic process has an effect. Therefore, the aim of our study is to compare the effects of intradialytic high-intensity intermittent exercise training and moderate-intensity exercise training on dialysis effectiveness, functional capacity and quality of life in hemodialysis patients.

Interventions

High Intensity Interval Training Group

Moderate Intensity Training Group

Sponsors

Istanbul University - Cerrahpasa
CollaboratorOTHER
Yasemin ASLAN KELEŞ
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)

Eligibility

Sex/Gender
ALL
Age
20 Years to 65 Years
Healthy volunteers
No

Inclusion criteria

* Between the ages of 20-65 * Having Stage 5 (ESRD) CRF according to GFR * Literate * Cooperative * Dialysis treatment for at least three months

Exclusion criteria

* History of myocardial ischemia in the last 6 months * Uncontrollable diabetes mellitus, * Uncontrollable hypertension * Heart failure * Malignant disease * Mental retardation * Illiteracy * Uncooperative * Neurological or orthopedic disability

Design outcomes

Primary

MeasureTime frameDescription
Dialysis Adequacy8 weeksKt/V
6 Minute Walking Test8 weeksFunctional Capacity
5X Sit-to-Stand Test8 weeksFunctional Capacity
Kidney Disease Quality of Life-368 weeksLife Quality

Secondary

MeasureTime frameDescription
Visual Analogue Scale8 weeksTo evaluate Fatigue. Each line is 100 mm in length - thus, scores fall between 0 and 100.Scoring : 0 : not all tired 100: extremely tired (left end of scale=not tired at all, right end of scale=extremely tired)
Quadriceps muscle strength8 weeksMuscle testing with dynamometer
Beck Depression Scale8 weeksMild depression (11-17 points) Moderate depression (18-29 points) Severe depression (30-63 points)

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026