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Evaluation of Non-Compressive Myelopathy in a Sample of Egyptian Patients

Evaluation of Non-Compressive Myelopathy in a Sample of Egyptian Patients

Status
UNKNOWN
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT05257330
Enrollment
50
Registered
2022-02-25
Start date
2022-01-01
Completion date
2022-07-31
Last updated
2022-02-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Myelopathy, Non-Compressive

Brief summary

An observational study will be conducted in the Department of Neurology at AlAzhar University Hospitals To study the etiological factors of non-compressive myelopathy in a sample of Egyptian patients

Detailed description

Myelopathy is a collective term referring to any pathologic condition or neurologic deficit related to the spinal cord. Myelopathies are a frequent and potentially disabling neurologic emergency.(Sarbu et al., 2019). Diseases of the spinal cord often have devastating consequences and imaging studies are indispensable for their diagnosis. The diagnostic approach must be based on the clinical context, the time elapsed since the onset of symptoms and signs, and the imaging findings (Herrera et al., 2020). Myelopathies may be compressive or non-compressive, regarding to subarachnoid space obstruction (Kundu et al., 2018). Noncompressive myelopathy (NCM) is described as spinal cord involvement without detectable clinical and radiological evidence of spinal cord compression causing neurological deficit (Thangaraj et al., 2019). There have been a few studies that have investigated Noncompressive myelopathy (NCM) in Africa as part of nontraumatic myelopathy. With very few studies focusing on NMOSD, Most of them focus on extrinsic compression and infectious diseases as important causes of myelopathy (Musubire et al., 2021) Comprehensive data on Egyptian patients with Non-compressive myelopathy (NCM) in the light of newer diagnostic criteria and serological tests are lacking. No study has been conducted to study the clinico-radiological profile of Non-compressive myelopathy (NCM) so far. In this study, we are putting an effort to convey our experience on etiological pattern of Non-compressive myelopathy (NCM) with special reference to its radiological features.

Interventions

DIAGNOSTIC_TESTCSF Examination

Lumbar puncture for CSF Examination

Sponsors

Al-Azhar University
Lead SponsorOTHER

Study design

Observational model
CASE_ONLY
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
2 Months to 100 Years
Healthy volunteers
No

Inclusion criteria

\- Patients with acute, subacute, or chronic neurologic dysfunction (motor and sensory deficit, sphincteric involvement, and a well-defined upper sensory segmental level) consistent with myelopathy (with or without coexisting encephalopathy, neuropathy, or radiculopathy).

Exclusion criteria

* 1\) Patients of myelopathy who did not undergo magnetic resonance imaging (MRI) of the spinal cord. 2) Spinal cord compression on MRI explaining patient's neurologic dysfunction. 3) History of previous trauma, acute coma and patients with definite cerebral symptoms incompatible with spinal pathology (e.g., aphasia, hemianopia, neglect, facial involvement). 4) Motor neuron disease (MND) 5)Degenerative ataxias.

Design outcomes

Primary

MeasureTime frameDescription
To study the etiological factors of non-compressive myelopathy in a sample of Egyptian patients6 monthsstudy the clinico-radiological profile of Non-compressive myelopathy

Countries

Egypt

Contacts

Primary ContactIslam S Al-Emam, MSC
eslamsalman211@gmail.com+201027759946
Backup ContactAbdel-Ghaffar Iٍ Fayed, Lecturer
drfayed1984@azhar.edu.eg+20 111 870 6806

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026