Vasodilation, Hypoxia
Conditions
Brief summary
The purpose of this project is to identify sex-related differences in the effect of hypoxia on sympathetic vascular transduction.
Interventions
DRUGPropranolol Pill
Participants will receive a β-blockade (propranolol pill, 1 mg/kg dosed based on participant weight).
DRUGPlacebo
Participants will receive a placebo in pill form.
Sponsors
American Heart Association
University of Missouri-Columbia
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* healthy adult men and women; * 18-45 years of age; * BMI 18-30 kg/m2; * non-pregnant/non-breastfeeding; * non-nicotine users;
Exclusion criteria
* Pregnancy, breastfeeding, hormonal contraceptives * Diagnosed sleep apnea * Current smoking/Nicotine use/drug use * Nerve/neurologic disease * Cardiovascular, hepatic, renal, respiratory disease * Blood pressure ≥140/90 mmHg * Diabetes, Polycystic ovarian syndrome * Communication barriers * Prescription medications * Recent COVID-19 diagnosis with symptoms
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Forearm Blood Flow | Change from baseline to 5 minutes | Measured with venous occlusion plethysmography (mL/dL/min) |
Countries
United States
Outcome results
None listed