Stroke
Conditions
Brief summary
Altered brain networks, including cognitive, motor, and language networks, are investigated by intensive cognitive rehabilitation in subacute stroke patients.
Interventions
PROCEDURECognitive rehabilitation
Intensive cognitive rehabilitation by cognitive therapist for 1 hour on every working 20 days (4 weeks) during the subacute stroke phase
Sponsors
Samsung Medical Center
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
19 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Patients aged 19 to 80 years * Patients with subacute stroke within 2 weeks of onset * First-ever stroke * Supratentorial stroke * Less than 8 SAFE (shoulder abduction, finger extension) points * Less than 35 FMA Upper scores * MEP (motor evoked potential) negative * Not more than 24 K-MMSE (Korean Mini-Mental State Examination) score
Exclusion criteria
* Difficult to communicate due to severe language impairment. * Accompanied by an existing serious neurogenic disease * Existing significant psychiatric disorders such as major schizophrenia, bipolar disorder * If there are difficulties in conducting the research * Any patients who are judged by the investigator to be difficult to participate in this study * Patients with contraindicated MRI scans
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Strength of connectivity in brain network obtained from MRI neuroimaging data | Change in strength of connectivity after intensive cognitive rehabilitation for 4 weeks | Participants' MRI neuroimaging data are acquired at pre- and post-intervention. Brain network can be constructed using MRI neuroimaging data, and strength of connectivity can be calculated in the brain network. Strength of connectivity has a value between -1 and 1. |
Countries
South Korea
Outcome results
None listed