Epilepsy, Refractory
Conditions
Brief summary
record fast ripples with novel intracranial electrodes with micro-tetrodes to improve the identification of epileptogenic zone (EZ) and investigate the neuronal circuits underlying brain dynamics associated with epilepsy
Detailed description
This study would improve the localization of the epileptogenic zone and reduce the overall duration of monitoring, especially in patients who do not experience a sufficient number of seizures during the implantation period. In addition, it would be possible to use micro-electrodes and propose a better surgical treatment to some patients whose preliminary assessment with macro-electrodes has not provided significant results. Finally, the data collected during this study will help us to further understand pathological brain activity and to describe the neuronal circuitry that gives rise to cortical signals and the relationships between them (from spindles to high frequency oscillations).
Interventions
DEVICEmacro-micro tetrodes for intracranial recording
novel design of tetrode micro electrodes within the standard macro intracranial electrodes used clinically for identification of the epileptogenic zone
Sponsors
Adrien Peyrache
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* inclusion criteria is determined based on the clinical diagnosis of the refractory epilepsy and the admissibility of the patient for the stereoelectroencephalography (sEEG) procedure
Exclusion criteria
* severe psychiatric disorders, * severe agitation during their crisis * contraindication for performing an MRI: claustrophobia, a cardiac or neural stimulator, ferromagnetic surgical clips, cochlear implants, intraocular metallic foreign body or in the nervous system, * contraindication to intracerebral investigation (macro-electrodes): ongoing infection, severe associated pathology (cardiac, pulmonary, renal, hepatic), pregnant or nursing women, * anti thrombotic ongoing treatment.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| evaluate the recording of fast ripples (FRs) and single neuron activity in the brain with the micro tetrodes | 1 week after implant | sum of number of single units recorded and the number of fast ripples (FRs) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Efficiency of microelectrodes compared to macroelectrodes | 10 days after implant | proportion and quality of the FRs recorded by the macro-blocks immediately adjacent to the microelectrodes located in the EZ |
Countries
Canada
Contacts
Primary ContactAdrien Peyrache, PhD
Backup ContactBirgit Frauscher, MD, PhD
Outcome results
None listed