Obstructive Sleep Apnea
Conditions
Keywords
Obstructive Sleep Apnea, Continuous Positive Airway Pressure, Weight Gain
Brief summary
The effect of CPAP on weight and fluid homeostasis will be assessed. Obstructive sleep apnea treatment-naive subjects will randomized to CPAP and control groups. Weight change, and changes in overnight urinary volume, intra and extracelullar volume, plasmatic B-type natriuretic peptide (BNP) and antidiuretic hormone (ADH) and urinary osmolality will be compared between groups.
Detailed description
There is a bidirectional relationship between Obstructive Sleep Apnea (OSA) and obesity. Although obesity can lead to OSA, patients with OSA are more likely to gain weight. The mechanisms that lead to weight gain during the treatment of OSA are not known. Some evidence supports the hypothesis that fluid accumulation could be a possible explanation for weight gain after treatment for OSA. The hypothesis is that one night of CPAP treatment promotes increased body weight and reduced diuresis in patients with OSA. Participants will be submitted to 2 consecutive nights of polysomnography (PSG). A baseline PSG will be performed during the first study visit. During the second study night, participants will be randomized into two groups, CPAP and control (repeat baseline PSG). Overnight urinary volume will be determined. Intra and extracellular water volume will be assessed using electrical bioimpedance before bedtime and just after the subject wakes up. Plasmatic BNP and ADH and urinary osmolality will also be determined during each morning following PSG.
Interventions
DEVICEContinuous Positive Airway Pressure
Continuous Positive Airway Pressure will be used during the second night of polysomnography .
Sponsors
University of Sao Paulo General Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Patients with a diagnosis of Obstructive Apnea Sleep * Over 18 years of age * No previous treatment with Continuous Positive Airway Pressure
Exclusion criteria
* Congestive heart failure * Renal insufficiency * Hepatic failure * Urinary incontinency * Diuretic therapy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Weight change | After 6 hours of Continuous Positive Airway Pressure treatment | Weight change with just one night of CPAP treatment. |
| Diuresis change | After 6 hours of Continuous Positive Airway Pressure treatment | diuresis change with just one night of CPAP treatment. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Urinary osmolarity | After 10 hours of the nocturnal polysomnography | Urine will be collected |
| Atrial natriuretic peptide and antidiuretic hormone | After 10 hours of the nocturnal polysomnography | Blood samples will be collected |
| Intra and extracellular fluid volume | Before the beginning and after 10 hours of the nocturnal polysomnography. | Intra and extracellular fluid volume accumulation will be assessed by bioelectrical impedance |
Countries
Brazil
Outcome results
None listed