Psoriasis
Conditions
Brief summary
Psoriasis is an immune-mediated chronic inflammatory skin disease associated with increase interaction of inflammatory mediators like adipokines. Pigment epithelium-derived factor (PEDF) is one of the most abundant adipokines and have anti-angiogenesis effect. There is a study showed that PEDF level is up-regulated in the sera of psoriasis patients.
Interventions
OTHERserum samples and punch skin biopsies
we will take serum samples from psoriasis patients and healthy controls and skin punch biopsies from lesional and non-lesional areas in psoriasis patients.
Sponsors
Sohag University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SCREENING
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Healthy volunteers
Yes
Inclusion criteria
Patients with psoriasis and group of age and sex-matched healthy volunteers will be included as a control group.
Exclusion criteria
* Pregnancy. * Patients with other inflammatory skin disorders. * Patients on antioxidants or anti-inflammatory drugs. * Patients on topical or systemic treatment for psoriasis in the last 4 weeks prior to enrollment in the study. * Patients on systemic retinoids (Acitretin). * Obesity: body mass index (BMI ) \> 30. * Malignancies e.g squamous cell carcinoma. * Viral warts. * Diabetes. * Hypertension.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| changes in serum and tissue levels of (PEDF) in patients with psoriasis | 12 months | evaluate serum and tissue level of (PEDF) in patients with psoriasis. |
Countries
Egypt
Contacts
Primary ContactOmnia Ahmed, Resident of Dermatology
Outcome results
None listed