Evaluation of Correlations Between Radiologic Features and Pathologic Subtypes of GGO LUAD Via WMS (ECTOP-1011)

Evaluation of Correlations Between Radiologic Features and Pathologic Subtypes of Ground Glass Opacity Featured Lung Adenocarcinoma Via Whole-Mount Section

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05252676

Enrollment

103

Registered

2022-02-23

Start date

2021-10-01

Completion date

2022-12-01

Last updated

2023-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Adenocarcinoma of Lung

Keywords

Ground glass opacity

Brief summary

This study is one of the Eastern Cooperative Thoracic Oncology Projects (ECTOP-1011). It aims to evaluate the correlations between radiologic features and pathologic subtypes of ground glass opacity featured lung adenocarcinoma via whole-mount section.

Detailed description

The pathological lepidic growth pattern was believed to relate to the ground-glass component, whereas invasive adenocarcinoma patterns relate to the solid component. However, the solid components might be fibrosis rather tumor; and previous studies demonstrated the ground-glass components might be invasive lesions. Therefore, it is of considerable significance to establish the correlations between radiologic features and pathologic subtypes of ground glass opacity featured lung adenocarcinoma.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Ground glass opacity featured lung nodule diagnosed by thin-section computed tomography(TSCT) * Pre-operation clinical IA stage * Pulmonary lobectomy or segmentectomy * Provision of informed consent

Exclusion criteria

* Postoperative diagnosis of non-adenocarcinoma or mucinous adenocarcinoma * The surgical specimens fail to satisfy requirement of inflation and formalin fixation

Design outcomes

Primary

Measure	Time frame	Description
Evaluation of correlations between radiologic features and pathologic subtypes	about 14 days	Evaluation of correlations between radiologic features and pathologic subtypes of ground glass opacity featured lung adenocarcinoma

Secondary

Measure	Time frame	Description
Specificity, Sensitivity, and Repeatability	about 14 days	The specificity, sensitivity, and repeatability of invasiveness diagnosis based on the Whole-Mount Section

Countries

China

Outcome results