Acute Myeloid Leukemia
Conditions
Keywords
Acute Myeloid Leukemia, Sepsis score, National Early Warning Score (NEWS), quick Sequential Organ Failure Assessment (qSOFA), chemotherapy-induced febrile neutropenia, Antibiotics prophylaxis
Brief summary
Evaluation of Infective Risk, Efficacy of Bacterial Prophylaxis and Validation of sepsis scores NEWS (National Early Warning Score) and qSOFA (Quick Sequential Organ Failure Assessment) in Patient With Acute Myeloid Leukemia Treated With Intensive Chemotherapy
Interventions
None listed
Sponsors
A.O.U. Città della Salute e della Scienza
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Diagnosis of non M3 Acute Myeloid Leukemia according to WHO (World Health Organization) 2008 criteria * Age \>= 18 years and \<= 70 years * Patient had received intensive chemotherapy either as induction or consolidation regimen * Period of observation: January 2001 - December 2019 * Written informed consent
Exclusion criteria
* Diagnosis of Acute Promyelocytic Leukemia (M3 AML) * Age \< 18 or \>70 years * Patient had not received intensive chemotherapy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Mortality risk | At baseline (fever onset), change at 24 hours from baseline, change at 48 hours from baseline | Ability of NEWS and qSOFA score to predict mortality risk calculating the area under the ROC (receiver operating characteristics) curve called AUROC (area under the ROC curve) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Amine requirement | At baseline (fever onset), change at 24 hours from baseline, change at 48 hours from baseline | Ability of NEWS and qSOFA score to predict vasoactive drugs requirement calculating the area under the ROC (receiver operating characteristics) curve called AUROC (area under the ROC curve) |
| Respiratory failure | At baseline (fever onset), change at 24 hours from baseline, change at 48 hours from baseline | Ability of NEWS and qSOFA score to predict respiratory failure calculating the area under the ROC (receiver operating characteristics) curve called AUROC (area under the ROC curve) |
| Ventilation support | At baseline (fever onset), change at 24 hours from baseline, change at 48 hours from baseline | Ability of NEWS and qSOFA score to predict ventilation support necessity calculating the area under the ROC (receiver operating characteristics) curve called AUROC (area under the ROC curve) |
| Systemic Inflammatory Response Syndrome (SIRS) development | At baseline (fever onset), change at 24 hours from baseline, change at 48 hours from baseline | Ability of NEWS and qSOFA score to predict SIRS development calculating the area under the ROC (receiver operating characteristics) curve called AUROC (area under the ROC curve) |
| Bloodstream infections | From date of fever onset until the date of fever resolution, assessed up to 60 days | Ability of NEWS and qSOFA score to predict severity of bloodstream infection calculating the area under the ROC (receiver operating characteristics) curve called AUROC (area under the ROC curve) |
| Number of infections | From date of neutrophils count <500/mmc until the day of neutrophils count >=500/mmc, assessed up to 60 days | Cumulative incidence of infections in patients with levofloxacin prophylaxis vs. patients without levofloxacin prophylaxis |
| Intensive care unit (ICU) admission | At baseline (fever onset), change at 24 hours from baseline, change at 48 hours from baseline | Ability of NEWS and qSOFA score to predict ICU admission calculating the area under the ROC (receiver operating characteristics) curve called AUROC (area under the ROC curve) |
Countries
Italy
Contacts
Primary ContactChiara Frairia, MD
Outcome results
None listed