Early Vitrectomy for Endophthalmitis After Cataract Surgery

Outcomes of Early Vitrectomy for Endophthalmitis After Cataract Surgery in Delta Population, Egypt, 2015-2020.

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05249413

Enrollment

Registered

2022-02-21

Start date

2015-01-02

Completion date

2022-01-15

Last updated

2022-02-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cataract, Endophthalmitis, Retinal Detachment, Vitreous Detachment

Keywords

endophthalmitis, cataract, vitrectomy, retinal detachment

Brief summary

Post-operative infectious endophthalmitis is devastating condition that causes a diffuse intraocular inflammation and may lead to blindness. Acute post-operative endophthalmitis usually presented within 6 weeks of intraocular procedure and diagnosis is confirmed by clinical examination and by the aid of B-scan ultrasonography.

Detailed description

There is no consensus regarding the timing of vitrectomy in cases with endophthalmitis after cataract surgery. The Endophthalmitis Vitrectomy Study concluded that vitrectomy should be preserved for cases with only light perception. The advances in posterior segment machines and small gauge cannulas decrease the incidence of intra-operative complications and encourage for early intervention in cases with endophthalmitis after primary cataract surgery.

Interventions

PROCEDUREEarly 23-gauge pars-plana vitrectomy

pars-plana vitrectomy for management of acute post-operative endophthalmitis.

Study design

Observational model

CASE_ONLY

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

3 Years to 80 Years

Healthy volunteers

Inclusion criteria

* Acute onset endophthalmitis within 6 weeks after primary cataract surgeries. * Patients had undergone early pars-plana vitrectomy within 48 hours of their confirmed diagnosis.

Exclusion criteria

* Patients were diagnosed as endogenous or chronic endophthalmitis. * Patients with a previous history of rupture globe surgery or trauma. * Patients who didn't complete the follow up period.

Design outcomes

Primary

Measure	Time frame	Description
Best-corrected visual acuity	Baseline and 3 months after intervention.	Changes in visual acuity from baseline and after early vitrectomy operation.

Secondary

Measure	Time frame	Description
Other prognostic factors	Baseline and 3 months after intervention.	Other factors that may influence the final visual outcome in cases with endophthalmitis as (intraocular tamponade, posterior vitreous detachment, systemic condition and virulence of causative organism)

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026