Colorectal Cancer Metastatic
Conditions
Keywords
liver transplantation, living donor, unresectable colorectal liver metastases
Brief summary
The goal of this study is to create a data registry to capture clinical, pathologic, and molecular data/outcomes for patients with metastatic colorectal cancer who undergo live donor liver transplantation.
Detailed description
The goal of this study is to create a data registry to capture clinical, pathologic, and molecular data/outcomes for patients with metastatic colorectal cancer who undergo live donor liver transplantation. Our primary outcome of interest was the OS and recurrence-free survival (RFS) of patients who underwent LDLT at our center.
Interventions
PROCEDURELiver transplantation
living donor liver transplantation
Sponsors
University of Rochester
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age ≥ 18 * Non-amenable to curative hepatic resection as defined by FLR \<30% * Histologically confirmed adenocarcinoma of the colon or rectum * Candidate for LDLT for colorectal liver metastasis per the University of Rochester liver transplant program
Exclusion criteria
* Not a candidate of the LDLT liver transplant protocol for treatment of colorectal liver metastasis. * Unwilling to consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| percentage of patients with recurrence free survival | 5 years | RFS proportions to be calculated at 1, 3, and 5 years with Kaplan Meier analysis |
| percentage overall survival | 5 years | OS proportions to be calculated at 1, 3, and 5 years with Kaplan Meier analysis |
Countries
United States
Contacts
CONTACTRoberto Hernandez-Alejandro, MD
CONTACTJennie Errigo
PRINCIPAL_INVESTIGATORRoberto Hernandez-Alejandro, MD
University of Rochester
STUDY_DIRECTORMatthew Byrne, MD
University of Rochester
Outcome results
None listed