Children, Eye Diseases, Ocular Surface Disease, Systemic Disease
Conditions
Brief summary
Use cohort research to analyze and compare eyes of healthy children and children with systemic diseases. Understand and analyze the incidence, characteristics and influencing factors of children's ocular surface diseases. Establish a multi-center children's eye data sharing platform to provide basic data support for the diagnosis and treatment of children's ocular surface diseases.
Detailed description
Use cohort research to analyze and compare eyes of healthy children and children with systemic diseases. Understand and analyze the incidence, characteristics and influencing factors of children's ocular surface diseases. Establish a multi-center children's eye data sharing platform to provide basic data support for the diagnosis and treatment of children's ocular surface diseases. All participants will be recruited from Zhongshan Ophthalmic Center, Sun Yat-sen University and Affiliated Foshan Maternity & Child Healthcare Hospital, Southern Medical University. Only children with written informed consent from their parents can participate in this study. Participants will be excluded for (1) age\>18; (2) previous use of orthokeratology lenses or low-concentration atropine; (3) allergy to compound tropicamide eye drop; (4) any history of ocular surgery. All participants will undergo optometry and biometric measurements by a trained team. The axial length (AL), central corneal thickness (CCT), anterior corneal radii of curvature, anterior chamber depth (ACD), lens thickness (LT), the curvature power of the central flat meridian (K1) and the central steep meridian (K2), the ocular surface and fundus will be measured. All measurements will be taken in room light condition (1000 lux).
Interventions
None listed
Sponsors
Affiliated Foshan Maternity & Child Healthcare Hospital, Southern Medical University ( Foshan Maternity & Child Healthcare Hospital)
Zhongshan Ophthalmic Center, Sun Yat-sen University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
No minimum to 18 Years
Healthy volunteers
Yes
Inclusion criteria
* 1\. Age≤18 * 2\. Cooperate with eye examination * 3\. Sign informed consent
Exclusion criteria
* 1\. Cannot cooperate with eye examination * 2\. The researcher believes that the patient is not suitable to participate in the study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| change of the lipid layer of tear film | baseline, 24th months | change of the lipid layer of tear film in nanometers |
| change of the non-invasive tear break-up time | baseline, 24th months | change of the non-invasive tear break-up time in seconds |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Eye axis length | baseline, 6th months, 12th months, 18th months, 24th months | Eye axis length in millimeters |
| vision | baseline, 6th months, 12th months, 18th months, 24th months | spherical equivalent in diopters |
| Anterior chamber depth | baseline, 6th months, 12th months, 18th months, 24th months | Anterior chamber depth in millimeters |
| central corneal thickness | baseline, 6th months, 12th months, 18th months, 24th months | central corneal thickness in millimeters |
| Lens thickness | baseline, 6th months, 12th months, 18th months, 24th months | Anterior chamber depth in millimeters |
| choroid thickness | baseline, 6th months, 12th months, 18th months, 24th months | choroid thickness in millimeters |
| Corneal curvature | baseline, 6th months, 12th months, 18th months, 24th months | Corneal curvature in diopters |
| non-invasive tear break-up time | 6th months, 12th months, 18th months | non-invasive tear break-up time in seconds |
| the lipid layer of the tear film | 6th months, 12th months, 18th months | the lipid layer of the tear film in nanometers |
| Retina thickness | baseline, 6th months, 12th months, 18th months, 24th months | retina thickness in millimeters |
| intraocular pressure | baseline, 6th months, 12th months, 18th months, 24th months | the intraocular pressure in mm Hg |
Other
| Measure | Time frame | Description |
|---|---|---|
| ocular surface disease index | baseline, 6th months, 12th months, 18th months, 24th months | It's a scale for the diagnostic score of dry eye. The total score ranges from 0 to 100, with higher scores indicating more severe symptoms. |
Contacts
Primary ContactYingting Zhu
Backup ContactRui Xie
Outcome results
None listed