Coronary Artery Disease
Conditions
Keywords
Spectral CT, Multi-Energy CT, Photon Counting Detector CT, PCD-CT
Brief summary
The main objective of this study is to evaluate the dose efficiency of coronary CT angiography (CTA) using a photon counting detector CT (PCD-CT) with the dose efficiency of coronary CT angiography of prior CT generations. 100 patients with a clinical indication for coronary CT angiography will be prospectively enrolled and undergo coronary CTA on a PCD-CT. For comparison, a matched retrospective cohort of 100 patients will be created who had undergone on a prior scanner generation (retrospective cohort).
Interventions
DIAGNOSTIC_TESTCardiac CTA on a photon-counting detector CT (PCD-CT)
Cardiac CTA will be performed on a dual-source photon-counting CT
DIAGNOSTIC_TESTCardiac CTA on a regular CT with Energy-Integrating Detector (EID-CT)
Cardiac CTA was performed on a dual-source CT with regular energy-integrating detector (EID-CT)
Sponsors
University Hospital Augsburg
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* indication for coronary CTA confirmed by board-certified radiologist ('justified indication' according to German/European radiation protection law) AND * patient (is able to give informed consent and) has given informed consent.
Exclusion criteria
* contraindications to (iodine based) iv contrast material: known allergy to iodine-based iv contrast, acute or high-grade chronic kidney insufficiency with an estimated glomerular filtration rate \< 30 ml/min/1.73 m², latent or manifest hyperthyroidism * known or suspected pregnancy * lactating mothers
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Intraluminal Enhancement of Coronary Arteries | 1 year | measured on thin-slice reconstructions, in Hounsfield units |
| Image Noise | 1 year | measured on thin-slice reconstructions, in Hounsfield units |
| Overall subjective image quality | 1 year | as assessed by board-certified and speciality-trained radiologists on a 5-point Likert scale |
| Dose-Length Product (DLP) | 1 year | Integrative descriptor for the x-ray dose applied during acquisition; can be read out from the scan protocol. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Diagnostic Accuracy of Coronary Artery Stenosis Assessment in Comparison with invasive catheter angiography | 1 year | Comparison in the subgroups of patients who als undergo invasive catheter angiography |
Contacts
Primary ContactFlorian Schwarz, MD
Outcome results
None listed