Impact of Insulin on Sympathetic Nervous System-mediated Peripheral Vasoconstriction

Status

Completed

Phases

Early Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05244694

Enrollment

Registered

2022-02-17

Start date

2020-08-06

Completion date

2021-06-25

Last updated

2023-02-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy, Insulin Resistance, Vasoconstriction

Brief summary

The purpose of this project is to determine if hyperinsulinemia attenuates sympathetic nervous system-mediated vasoconstriction in the human leg.

Interventions

DRUGInsulin

Priming dose then a constant infusion at 40 mU•m-2•min-1

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 45 Years

Healthy volunteers

Yes

Inclusion criteria

* healthy adult men and women; * 18-45 years of age; * BMI 18-30 kg/m2; * non-pregnant/non-breastfeeding; * non-nicotine users;

Exclusion criteria

* taking any medications known to affect metabolic, respiratory, cardiovascular, and/or autonomic functions Self-reported history of: * hepatic, renal, pulmonary, cardiovascular, or neurological disease; * stroke or neurovascular disease; * bleeding/clotting disorders; * sleep apnea or other sleep disorders; * diabetes; * smoking; * history of alcoholism or substance abuse, excessive alcohol consumption; * hypertension; * active cancer; * autoimmune disease; * immunosuppressant therapy

Design outcomes

Primary

Measure	Time frame	Description
Amount of leg blood flow	Change from baseline at minute 60	Measured with Doppler ultrasound (mL/min)

Secondary

Measure	Time frame	Description
Amount of muscle sympathetic nerve activity (MSNA)	Change from baseline at minute 60	MSNA burst incidence (bursts/100 heart beats)
Amount of cerebral blood flow	Change from baseline at minute 60	Measured with trans-cranial Doppler ultrasound (cm/s)

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 6, 2026