Ischemic Stroke
Conditions
Keywords
Ischemic Stroke, Optical Coherence Tomography Angiography, Retina
Brief summary
The study aimed to access the microvascular changes in the superficial capillary plexus (SCP) and deep capillary plexus (DCP) in patients with ischemic stroke and its different types using optical coherence tomography angiography.
Detailed description
Investigators used OCTA to quantitatively access the retinal microvasculature of SCP and DCP, aiming to detect the geometry changes of retinal microvasculature and FAZ in ischemic stroke patients and its different types.
Interventions
DEVICEOptical Coherence Tomography Angiography
Optical coherence tomography angiography (OCTA) is a novel non-invasive, non-dye and high-resolution imaging technique, allowing real-time quantitative evaluation of retinal vasculature and the structure of foveal avascular zone (FAZ).
Sponsors
Peking University Third Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
40 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
Patients who were diagnosed with ischemic stroke by MRI were scheduled for an OCTA examination. The diagnosis of ischemic stroke was obtained from previous diagnostic reports or electronic medical records, according to the diagnostic criteria from the Trial of Org 10172 in Acute Stroke Treatment (TOAST).
Exclusion criteria
1\) Retinal diseases or diseases affecting vessel structure in fundus photography, including age-related maculopathy; diabetic retinopathy, central serous chorioretinopathy, retinal pigment epithelial detachment and glaucoma); poor cooperation in ophthalmic examinations; high refractive error (\>+6.00 D or \<-6.00 D Spherical Equivalent); low-quality OCTA images (signal strength index \< 6/10). Inclusion criteria for healthy controls were no history of ischemic stroke or other neurological and ocular diseases.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Vascular Area Density(VAD) | immediately after meeting the inclusion and exclusion criteria | The total length in millimeters of perfused retinal microvasculature per unit area in square millimeters in the annular region of analyzed area |
| Vascular Fractal Dimension(VFD) | immediately after meeting the inclusion and exclusion criteria | A well-known parameter which indicates the degree of geometric complexity of vasculature |
| Vascular Orientation Distribution(VOD) | immediately after meeting the inclusion and exclusion criteria | The direction of each vascular pixel to indicate the trend of the blood flow |
| FAZ Area(FA) | immediately after meeting the inclusion and exclusion criteria | The total numbers of pixels in the FAZ region |
| FAZ Axis Ratio(FAR) | immediately after meeting the inclusion and exclusion criteria | The ratio between the major and minor axes of the fitted ellipse from the FAZ boundary. The axis ratio of a perfect circular FAZ is equal to 1 |
| FAZ Circularity(FC) | After meeting the inclusion and exclusion criteria | The ratio of the perimeter of the FAZ to the parameter of a circle with equal area, reflecting the degree of roundness of the FAZ |
| FAZ Roundness(FR) | immediately after meeting the inclusion and exclusion criteria | Similar to FC, but is less sensitive to irregular borders along the parameter of FAZ |
Countries
China
Contacts
Primary ContactHong Qi, PhD
Backup ContactHongyu Duan, MD
Outcome results
None listed