Metabolic Syndrome and Diabetic Neuropathy
Conditions
Brief summary
The components of metabolic syndrome (MetS), particularly obesity and dyslipidemia, are linked to peripheral neuropathy (PN) among patients with diabetes or even without diabetes. Several studies revealed that complementary and herbal medicine could provide a potential for PN management and MetS components. Thus, designing clinical trials with interventions combinations to achieve a considerable improvement is highly recommended. Hesperidin and diosmin, citrus-derived flavonoids, have been reported to possess anti-hyperlipidemic, anti-inflammatory, analgesic, antioxidant, antidiabetic, and anti-hypertensive effect with high tolerability and safety profile
Interventions
DIETARY_SUPPLEMENTdietary supplement flavonoids
patients were allocated to receive either hesperidin, diosmin, or combination of both and the fourth group was assigned as a control group without intervention
Sponsors
Beni-Suef University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
Type 2 diabetes adult patients who meet metabolic syndrome criteria and with diabetic neuropathy
Exclusion criteria
patients without any parameter of inclusion criteria
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| MNSI score for neuropathy | 12 weeks | neuropathy improvement if MNSI score decreased |
| metabolic syndrome components | 12 weeks | Waist circumference, (cm) |
Countries
Egypt
Outcome results
None listed