Pulmonary Arterial Hypertension
Conditions
Brief summary
In this study, the effects of kettlebell exercise training on functional capacity, dyspnea and activities of daily living in patients diagnosed with Pulmonary Arterial Hypertension (PAH) will be investigated.
Interventions
OTHERKettlebell Exercise
The exercise training plan for this group consists of 4 stages. Each stage lasts 2 weeks and consist of 5 kettlebell (KB) exercises. These exercises will continue from basic (single movement training) to advanced (comprehensive movement training) and is geared towards functional training. Participants will perform 2 sets of 12 repetitions of each exercise. Each training session is planned to last 45 minutes. The following exercises will be used in KB training: biceps curl, triceps extension, kettlebell swing (two-handed), kettlebell dead lift, kettlebell goblet squat, suitcase carry, waiter carry, bottoms up carry, farmer's walk, overhead carry, lunge, kettlebell row.
Sponsors
Istanbul University - Cerrahpasa
Saglik Bilimleri Universitesi
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients diagnosed with pulmonary arterial hypertension (PAH) by a specialist physician in accordance with the 2015 guideline for the treatment and diagnosis of pulmonary hypertension of the European Heart and Respiratory Societies (ERS/ESC), * Patients with stable pharmacological treatment, * Patients clinically stable at least last three months.
Exclusion criteria
* Presence of orthopedic or neurological problems that will affect functional tests and muscle strength measurement, * Recent surgical procedures, * Recent syncope, * Pregnancy, * Presence of severe left heart failure, * Presence of severe ischemic heart disease, * Hypertensive patients, * Patients who have problems in communicating.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Handgrip strength | 8 weeks | Hand grip strength will be measured with a digital hand dynamometer. |
| Task related oxygen uptake | 8 weeks | Cardiopulmonary data will be evaluated with mobile cardiopulmonary exercise test during daily activities. Participants will perform the following activities with mobile cardiopulmonary exercise test (CPET): putting on socks on both feet (sitting on a chair), putting on both shoes (sitting on a chair), putting on a coat (while standing), lifting material (placing 6 jars -each 400 gram- at chest-level height), sweeping the floor for 4 minutes, washing dishes for 4 minutes, go up and down stairs - 1 floor. There will be a 5 minute rest between all activities. |
| Functional capacity | 8 weeks | The 6-minute walk test will be performed. |
| Peripheral muscle strength | 8 weeks | Isometric muscle strength will be measured with a handheld dynamometer for elbow flexion, knee extension, knee flexion, shoulder flexion, shoulder abduction, hip flexion and m.serratus anterior. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Activity status | 8 weeks | This outcome will be assessed with the Duke Activity Status Index. As a result of scoring, a total score ranging from 0 to 58.2 is obtained. Higher scores indicate higher functional capacity. |
| Health-related quality of life | 8 weeks | This outcome will be assessed with the emPHasis-10. emPHasis-10 consists of 10 items and results in a score out of 50, where a higher score represents a higher symptom burden. |
| Activities of daily living | 8 weeks | This outcome will be assessed with the London Chest Activity of Daily Living Scale. It is a questionnaire consisting of fifteen items. Each item is given a score ranging from 0 to 5. Higher scores indicate greater limitation in activities of daily living. The total score can reach a maximum of 75 |
| Sleep quality | 8 weeks | This outcome will be assessed with the Pittsburgh Sleep Quality Index. The questionnaire consists of 19 individual items. Each item is given a score ranging from 0 to 3, providing an overall score ranging from 0 to 21, where lower scores denote a healthier sleep quality. |
Countries
Turkey (Türkiye)
Outcome results
None listed