Thyroid Eye Disease
Conditions
Keywords
Cornea- Tear film- AS-OCT
Brief summary
use the anterior segment optical coherence tomography (AS-OCT) to evaluate the tear meniscus parameters, total corneal thickness (CT), and epithelial thickness in active and inactive thyroid eye diseases (TED) patients and compare them with age-matched controls.
Detailed description
A prospective case-control clinical study. The study subjects were divided into 3 groups, group 1 of inactive thyroid patients, group 2 of active thyroid patients, and group 3 of healthy controls. The AS-OCT was used to measure lower tear meniscus parameters (tear meniscus height (TMH), tear meniscus depth (TMD), and tear meniscus area (TMA)), total CT and epithelial thickness
Interventions
DIAGNOSTIC_TESTAS-OCT
Optical Coherence Tomography (OCT) creates detailed cross-sectional images of the anterior and posterior segments using low coherence interferometry. OCT is a noninvasive, real-time method for evaluating the tear meniscus, total corneal thickness (CT), and corneal epithelial thickness
Sponsors
Minia University
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Inclusion criteria
* The inclusion criteria were patients with thyroid disorders with age between 20 to 60 years with no ocular manifestations
Exclusion criteria
* being younger than 20 or older than 60, presence of systemic diseases as diabetes mellitus (DM) and autoimmune diseases as rheumatoid arthritis (RA) that may cause dry eye, previous ocular surgery, use of contact lenses, smokers, pregnant women, and breastfeeding women.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Tear Meniscus Height | through study completion, an average of 6 months | represented by a line joining the points corresponding to the upper corneo-meniscus junction to the lower eyelid-meniscus junction |
| Tear Meniscus Depth (TMD): | through study completion, an average of 6 months | represented as the distance between the center of the upper boundary of the tear meniscus and the point at the bottom boundary where the cornea meets the eyelid |
| Tear Meniscus Area (TMA) | through study completion, an average of 6 months | triangular area formed by the corneal anterior boundary, anterior boundary of the lower eyelid and anterior borderline of the tear meniscus |
Countries
Egypt
Outcome results
None listed