Coronary Artery Disease
Conditions
Brief summary
The objective is to assess long-term clinical outcomes of patients in whom intervention of coronary lesions was deferred due to negative fractional flow reserve (FFR) and negative Instantaneous wave-free ratio (iFR) in a real-world patient population and to identify factors associated with deferred target lesion failure.
Detailed description
Fractional flow Reserve (FFR) evaluates functional significance of stenosis in intermediate coronary lesions. Instantaneous wave-free ratio (iFR) is considered noninferior to FFR and does not require adenosine administration. This study was done to assess long-term clinical outcomes and factors associated with target vessel revascularization (TVR) in patients with deferred revascularization based on negative FFR and iFR. Retrospective analysis of medical records of 345 patients with deferred revascularization at a tertiary care hospital , from January 2012 to January 2020 will be done.
Interventions
DIAGNOSTIC_TESTFractional flow reserve, instantaneous wave-free Ratio
Clinical outcomes observed for patients with moderate coronary lesions in whom coronary revascularization was deferred due to a negative physiologic study.
Sponsors
Aga Khan University Hospital, Pakistan
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Inclusion criteria
* Patients who had intermediate to severe coronary lesions on coronary angiogram. * Patients who had negative FFR \>0.80 or iFR \>0.89 and did not undergo immediate or planned revascularization on basis of negative physiologic assessment.
Exclusion criteria
* Patients younger than 18 years of age or those having positive FFR/iFR values irrespective of revascularization status were excluded. * Similarly, those who were lost to follow up and could not be traced via telephonic or were also excluded.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cardiac death | 29 months | Number of participants who died due to sudden cardiac arrest, sudden death due to acute MI and death due to heart failure or cardiogenic shock |
| Non-fatal myocardial infarction | 29 months | Number of patients suffering from Myocardial infarction but did not die. |
| Target vessel revascularization. | 29 months | Repeat PCI or bypass graft placement for a stenosis in another part of the vessel treated at the index PCI |
Countries
Pakistan
Outcome results
None listed