Delusion, Hallucinations, Parkinson Disease, Parkinson Disease Psychosis
Conditions
Brief summary
Parkinson's disease psychosis encompasses a range of symptoms, including minor phenomena, frank hallucinations, and delusions. Minor phenomena include passage hallucinations (fleeting sense of a person, animal or object passing in the periphery), presence hallucinations (feeling of nearby presence), and illusions (misrepresentation of external stimuli). Some forms of PD psychosis may be progressive. The primary objective of this study is to: 1\) To determine the cumulative probability of developing hallucinations or delusions over time in individuals with PD minor phenomena followed for 36 months.
Interventions
OTHERObservation of minor phenomena
observation twice a year over 3 years
Sponsors
ACADIA Pharmaceuticals Inc.
University of Rochester
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
30 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Parkinson's disease (as determined by Movement Disorders Society diagnostic criteria for clinically probable Parkinson's disease) * Parkinson's disease minor phenomena * ≥30 years of age * Proficient in English * Willing and able to provide informed consent
Exclusion criteria
* Any current or prior history of formed hallucinations or delusions * Current or prior treatment with an antipsychotic medication (regardless of indication) * Diagnosis of mania with psychotic features, bipolar or related disorder, depression with psychotic features, or a psychotic disorder * Unable or unwilling to complete study activities * Any medical or psychiatric comorbidity that, in the opinion of the investigator, would compromise study participation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cumulative probability of developing hallucinations or delusions over time | baseline to 36 months | Kaplan-Meier curves will be used to describe the cumulative probability of hallucinations and/or delusions over time. Participants will be determined to have met the primary endpoint if they have hallucinations and/or delusions on the basis of interview or initiate treatment with an antipsychotic medication. |
Countries
United States
Outcome results
None listed