SARS-CoV2 Infection, COVID-19
Conditions
Brief summary
SARS-CoV-2 transmission is dependent on multiple factors, which may be related to either host-virus interaction or the environment. While there have been several studies evaluation viral dynamics and transmission risk in adults, there is limited pediatric data available. The objective of this study is to characterize the period of communicability for children less than 19 years of age with SARS-CoV-2 infection with the Omicron variant.
Detailed description
The goal of our study is to assess the viral dynamics of SARS-CoV-2 infection in children \< 19 years with acute infection to inform public health practice. Specific Aims: 1. Describe the kinetics of SARS-CoV-2 viral load in children with acute SARS-CoV-2 infection 2. Assess the impact of various host factors on viral dynamics, including age (\<1 year, 1-4 years, 5-11 years, 12-18 years), symptoms, clinical severity (hospitalization vs. outpatient), comorbidities (immunocompromised vs. not immunocompromised), vaccination (none, 1 dose, 2 doses) 3. Estimate the time point at which children are less likely to be infectious 4. Assess the sensitivity of self-collected rapid antigen testing (RAT) in children, compared to PCR (e.g. assess RAT test performance in children)
Interventions
DIAGNOSTIC_TESTDaily SARS-CoV-2 PCR Testing for 10 days
Each participant will undergo daily SARS-CoV-2 PCR testing to assess viral dynamics
Sponsors
The Hospital for Sick Children
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
No minimum to 18 Years
Inclusion criteria
To be included in the study, the participant must be: 1. Less than 19 years of age 2. Have a positive molecular or rapid antigen test in the previous 48 hours 3. If symptomatic, onset of any COVID-19 symptom within last 72 hours. 4. If asymptomatic, evidence to support acute infection (e.g. negative PCR in the last 5 days, known household exposure where index case is clear) 5. Able to collect daily samples
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| SARS-CoV-2 Viral Load | 10 days | We will use prospective longitudinal quantitative reverse transcription PCR testing to measure the viral RNA trajectories for individuals in the study. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Rapid antigen test sensitivity | 10 days | We will describe the RAT positivity on Days 1 to 10 and evaluate the performance of RAT compared to PCR |
Countries
Canada
Outcome results
None listed