Ketoses, Metabolic
Conditions
Keywords
ketones, heart metabolism, kidney metabolism
Brief summary
The objective of this study is to make a comparison between 11C-acetate and 11C-Acetoacetate heart and kidney metabolism
Detailed description
Healthy people will have two positron emission tomography scan to perform. One, with a 11C-Acetate Tracer and the other with 11C-Acetoacetate. The results will allow to determine if both tracers are used in a similar way but the organs and see if the investigators can use the already validated analyse method for acetate to make acetoacetate analysis
Interventions
RADIATIONObservational heart and kidney on siemens TEP scan
Same as arm description
Sponsors
Nestlé Health Science Spain
Université de Sherbrooke
Study design
Allocation
NA
Intervention model
SEQUENTIAL
Primary purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE
Intervention model description
Participants will have to perform 2 scans one after the other
Eligibility
Sex/Gender
ALL
Age
18 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
* Aged between 18 and 55 * BMI between 18,5 and 28 * Healthy * Normal value for blood pressure
Exclusion criteria
* Taking drugs that could influence metabolism * Diabetes or prediabetes * Pregnancy or lactation * Participation in a intensive sport program * Being on a ketogenic diet * Any clinical abnomally in prescreen blood sample
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Mean in left ventricule myocradial blood flow | 30 minutes | Heart acetate metabolism measured by TEP scan |
| Mean in left ventricule myocardial blood flow | 30 minutes | Heart acetoacetate metabolism measured by TEP scan |
| Mean in Kidney acetate uptake | 30 minutes | Kidney acetate uptake measured by TEP scan |
| Mean in Kidney acetoacetate uptake | 30 minutes | Kidney acetoacetate uptake measured by TEP scan. |
Countries
Canada
Outcome results
None listed