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Understanding and Overcoming the Racial/Ethnic Inequalities in COVID-19 Vaccination Acceptance

Mind the Vaccination Gap: Understanding and Overcoming the Racial/Ethnic Inequalities in COVID-19 Vaccination Acceptance

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT05238428
Enrollment
4039
Registered
2022-02-14
Start date
2022-02-03
Completion date
2022-03-05
Last updated
2022-05-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Vaccine Refusal

Keywords

COVID-19 vaccination acceptance, vaccine hesitancy, trust, health inequality, racial/ethnicity

Brief summary

With the constant threat of new epidemic waves and the emergence of variants, COVID-19 resilience can only be attained when a sufficient level of immunity is achieved. Yet, in the US and the UK, COVID-19 vaccination campaigns have failed to secure consistent vaccination acceptance in racial/ethnic minority communities. Despite racial/ethnic minorities being more at risk from COVID-19, they are less vaccinated than the White majority. The investigators propose that current vaccination invitation messages are deemed less trustworthy by racial/ethnic minorities than the White majority and that this might partly explain reduced vaccination acceptance. To provide causal evidence of the role of trust and actionable insights, the investigators will experimentally assess the benefits of new invitation messages to receive the COVID-19 booster dose in large, racially/ethnically diverse samples in the US and the UK. Results will evidence how to increase message and source trustworthiness to foster trust and vaccination acceptance across racial/ethnic groups.

Interventions

BEHAVIORALTrust boost

The investigators adapt the wording of the vaccination invitation to foster trust and increase vaccination acceptance.

Sponsors

University of Southern California
CollaboratorOTHER
Department of Health and Social Care
CollaboratorUNKNOWN
Kingston University
CollaboratorOTHER
University of Essex
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Masking description

Participants will read and evaluate 4 versions of the vaccination invitation. The condition will be selected randomly by the Qualtrics algorithm (with an even selection rate). The four invitations will be presented to each participant in a random order based on the Qualtrics randomisation algorithm.

Intervention model description

In a 4 x 4 experimental design, the investigators will manipulate the content of the vaccination invitation message in within-subject and the message source in between-subjects. Each participant will hence read four versions of the COVID-19 booster vaccination invitation message sent by one of the four possible sources.

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes

Exclusion criteria

* if participants complete the study in less than 5 minutes * if participants complete the study without paying attention (as indicated by their answers to two attention check questions)

Design outcomes

Primary

MeasureTime frameDescription
Trust perceptionimmediately after interventionPerceived trustworthiness of the vaccine invitation. Participants will rate how trustworthy is the invitation message on a 5 point Likert scale (1: Untrustworthy 3: Not sure, 5: Trustworthy)
Vaccination appointment bookingimmediately after interventionLikelihood to book a vaccination appointment via the message. Participants will report if they would use the link in the message to book their vaccination appointment on a 5 point Likert scale (1: No, I would not, 3: Not sure/maybe later, 5: Yes, I would)

Countries

United Kingdom

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026