Generalized Vitiligo
Conditions
Brief summary
As part of this study, you may have a procedure called phototherapy which involves either VL-UVA or NB-UVB irradiation. NB-UVB phototherapy is not experimental in vitiligo, but use of VL-UVA1 phototherapy in vitiligo is. The purpose of this pilot study is to determine whether VL-UVA1 or NB-UVB phototherapy more efficiently induces repigmentation in patients with generalized vitiligo.
Interventions
PROCEDUREVisible Light-Ultraviolet A Light or Narrowband-Ultraviolet B phototherapy
Patients will have different kinds of light shined on different areas
Sponsors
Henry Ford Health System
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
The subject serves as their own control.
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Subjects ≥ 18 years of age with a diagnosis of generalized vitiligo * Subjects on a stable topical/oral regimen for the past 3 months and continuing on a stable regimen * Subjects able to understand the requirements of the study * Subjects able and willing to sign informed consent
Exclusion criteria
* Subjects on photosensitizing medications * Subjects receiving any concurrent phototherapy * Subjects who plan to use tanning parlors or expose themselves to excess sunlight * Subjects with known photosensitivity disorder * Subjects with apparent phototoxicity * Subjects with unstable vitiligo * Subjects currently using bleaching agents * Subjects who are pregnant, lactating, or planning on becoming pregnant * Subjects who in the opinion of the investigator/sub-investigator, are not appropriate candidates for this study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in depigmentation of vitiligo lesion | 13 measurements over 26 visits | Change in pigment will be assessed by colorimetry which measures change in pigment |
| Change in melanin content of vitiligo lesion | 13 measurements over 26 visits | Change in pigment will be assessed by diffuse reflectance spectroscopy which will measure the melanin content and dyschromia |
Countries
United States
Outcome results
None listed