Autism Spectrum Disorder
Conditions
Keywords
Autisme Spectrum Disorders, Motricity, Cognitive disorders, Behaviour, motor skill differences
Brief summary
This research is a case-control study aiming to characterize motor peculiarities (objective quantitative and qualitative measures) and its psycho-physiological correlates of children with ASD.
Detailed description
The main objective is to measure jointly and in an automated and standardized manner the performance and motor patterns within the framework of tasks measuring the performance and patterns of general motor skills (postures, walking, coordination overall), fine motor skills (graphics, pointing task) and oculomotricity (visual orientation and control). The secondary objective is to investigate the relationships between motor difficulties and cognitive and social disorders found in children with ASD. * Compare the motor performance data in the 3 major motor domains with each other (overall, fine and oculomotor); * Evaluate intergroup differences based on clinical characteristics (ADOS-2, ADI-R, CARS 2 scores), age, IQ, socio-communication profile score (SRS-2) and presence comorbidities (TADH, TDC).
Interventions
BEHAVIORALTesting of general motor skills, fine motor skills and occulomotricity
Recording of participant's performance during eye, fine motor and gross motor tests; Children's gross motor skills will be assessed through a biomechanical analysis. Eye movements will be recorded using the eye-tracking system (Tobii Pro TX300). The technique used is the corneal reflection technique.
BEHAVIORALQuestionnaires
Passing self and hetero questionnaires.
Sponsors
Centre Hospitalier Charles Perrens, Bordeaux
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
6 Years to 11 Years
Healthy volunteers
Yes
Inclusion criteria
: All participants : * Be between 6 and 11 years old * Mastery of the French language * Be affiliated with a Social Security scheme or benefit from affiliation by a third person * Both parents (or the holder of legal authority) have read, understood and signed the study consent * Be affiliated with social security Participants with ASD should also verify the following inclusion criteria: * Being diagnosed with ASD (DSM-V)
Exclusion criteria
: All participants : * Refusal to participate in the research on the part of the participant and / or holders of parental authority. * Be a person benefiting from enhanced protection, namely : persons deprived of their liberty by a judicial or administrative decision, persons staying in a health or social establishment. * Have uncorrected visual or hearing problems * To have concomitant psychotropic drug treatments not stabilized, initiated in the last 2 months: antipsychotics, mood stabilizers, anti-epileptics, psychostimulants, antidepressants. * Have a motor handicap of the upper or lower limbs, fitted or not. * Have diagnosed neurological or psychiatric disorders, present a general or metabolic pathology having a known impact on the child's motor skills (eg: Epilepsy, Tics and Gilles de la Tourette Syndrome, Intellectual Deficiency, Neuromuscular Syndrome, Metabolic Neurological Syndrome , neoplasms) * Suspicion of low intellectual efficiency if at least one of the two subtests (Similarities or Matrices) of WISC V (retrieved from the medical file if the TSA participant) presents a result (standard score) strictly lower than 7. Participants without ASD : * Participant with ADHD (Attention Deficit Disorder with or without Hyperactivity) or CDD (Developmental Coordination Disorder)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Measurement performance of fine motor skills (graphics, pointing task) | At 3 month | Jointly and in an automated and standardized manner, measure performance in the context of tasks measuring the performance and patterns of general motor skills (postures, walking, overall coordination), fine motor skills (graphics, pointing task) and oculomotricity (visual orientation and control). |
| Measurement performance of general motor skills with biomechanical analysis | At 3 month | Jointly and in an automated and standardized manner, measure motor patterns in the context of tasks measuring the performance and patterns of general motor skills (postures, walking, overall coordination), fine motor skills (graphics, pointing task) and oculomotricity (visual orientation and control). |
| Measurement of oculomotricity with eye-tracking system (visual orientation and control) | At 3 month | Jointly and in an automated and standardized manner, motor patterns in the context of tasks measuring the performance and patterns of general motor skills (postures, walking, overall coordination), fine motor skills (graphics, pointing task) and oculomotricity (visual orientation and control). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Motor performance : success, error rate (%) | At visit 1 and visit 2, an average of 3 months | — |
| Motor performance : task duration (ms), reaction time (ms) and latency (ms) | At visit 1 and visit 2, an average of 3 months | — |
| IQ as assessed using WISC IV | At visit 1 and visit 2, an average of 3 months | — |
| Score of socio-communicative skills as assessed using Social Responsiveness Scale | At visit 1 and visit 2, an average of 3 months | Social Responsiveness Scale : Min = 30, Max=90 Higher scores mean a worse outcome |
| ADHD as assessed using Conners-3 | At visit 1 and visit 2, an average of 3 months | — |
| Developmental Coordination Disorder as assessed using Developmental Coordination Disorder Questionnaire | At visit 1 and visit 2, an average of 3 months | Developmental Coordination Disorder Questionnaire : Min = 15, Max = 75 Higher scores mean a better outcome |
| ASD Clinical Assessment as assessed using Childhood Autism Rating Scale | At visit 1 and visit 2, an average of 3 months | Childhood Autism Rating Scale : Min = 0, Max = 100 Higher scores mean a worse outcome |
Countries
France
Contacts
CONTACTAnouck AMESTOY, MD
CONTACTHelen SAVARIEAU
STUDY_DIRECTORAnouck AMESTOY, MD
Physician
Outcome results
None listed