Secretin in Refeeding

Secretin Levels in Refeeding-induced Polyuria (Cross Section)

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05235867

Enrollment

Registered

2022-02-11

Start date

2022-02-01

Completion date

2027-12-31

Last updated

2026-02-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anorexia in Adolescence

Brief summary

Patients with restrictive-type anorexia nervosa who are admitted to the hospital for feeding often urinate excessive amounts. Others have changes in the way that they handle acid and base. These issues prolong hospitalizations. Current data suggest that one hormone--named secretin--may control both urine output and how the body handles acid and base. This study will evaluate whether secretin levels are different in anorexic patients who urinate an excessive amount compared to those who urinate normal amounts. For this study, patients will have one extra blood draw before and after one meal during their hospitalization. The blood draw before the meal coincides with a standard of care blood draw. Also after the meal, subjects will be asked to provide one extra urine sample. Information from subject's medical records will also be used.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

13 Years to 24 Years

Healthy volunteers

Inclusion criteria

* Group 1: * male and female patients * age 13-24 years * diagnosis of restrictive-type anorexia nervosa * hospitalization for nutritional support * \>4 cc/kg/day of urine output (a.k.a. "fluid dumpers"; n=5) * Group 2: * male and female patients * age 13-24 years * diagnosis of restrictive-type anorexia nervosa * hospitalization for nutritional support * \<2 cc/kg/d of urine output (a.k.a. "non-dumpers"; n=5)

Exclusion criteria

* 5150 hold * Anti-depressant, anti-psychotic, or anticonvulsant medications * Previous hospitalization within the past 6 months * Underlying metabolic disorder not related to anorexia nervosa (including chronic kidney disease, renal tubular disorders, and underlying endocrine disorders) * Pregnancy * NG or G-tube feeds after day 2 of hospitalization * \> 10% of nutritional needs from supplemental feeds

Design outcomes

Primary

Measure	Time frame	Description
Change in secretin	1 hour	Change in secretin value from pre- to post- meal

Secondary

Measure	Time frame	Description
Change in serum bicarbonate	1 hour	Change in bicarbonate value from pre- to post- meal

Countries

United States

Contacts

CONTACTMisciel Macaraig

mbmacaraig@mednet.ucla.edu310-825-0922

Outcome results