Postoperative Hyperalgesia
Conditions
Brief summary
To explore the effect of daytime variation on postoperative hyperalgesia induced by opioids. Patients receiving endoscopy surgery under general anesthesia during 08:00-12:00(morning group, n=30) and 14:00-18:00(afternoon group, n=30) using remifentanil for anesthesia maintenance were respectively included. Postoperative hyperalgesia at PACU and 24 hours after surgery were assessed through mechanical pain measurement. Comparative analysis of postoperative hyperalgesia levels, pain and analgesic requirements between morning group and afternoon group were performed.
Interventions
DRUGRemifentanil
Remifentanil was used for maintenance of anesthesia.
Sponsors
The Second Affiliated Hospital of Chongqing Medical University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* American Society of Anesthesiologists classification I-II * Abdominal endoscopy surgery * Estimated surgery duration 1-2h * Right handedness * Voluntarily receive postoperative intravenous controlled analgesia
Exclusion criteria
* Heavy smoking or alcohol dependence * Puerpera or lactation women * History of chronic pain * Analgesic use within one month before surgery * Allergy to opioids * Can not follow with the study procedure
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Postoperative hyperalgesia when discharged from postanesthesia care unit | from the 30 minutes before the surgery until to the time when discharged from postanesthesia care unit, assessed up to about 2 hours | The ratio of pressure pain threshold when discharged from PACU compare to before surgery |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Postoperative hyperalgesia at 24 hours after surgery | from the 30 minutes before the surgery until to 24 hours after surgery | The ratio of pressure pain threshold at 24 hours after surgery compare to before surgery |
| Postoperative pain intensity | from the time when the surgery was completed until to 24 hours after surgery | Pain intensity was assessed by numerical rating scale (0-10, 0 represents painless; 10 represents intolerable pain) |
| Postoperative analgesic requirements | from the time when the surgery was completed until to 24 hours after surgery | Analgesic requirements was assessed by recording the volume of patient controlled analgesia pump |
| Plasma concentration of remifentanil and sufentanil | from 30 minutes before the surgery until to the time after stop infusion of remifentanil, assessed up to about 2 hours | Determined by Elisa test |
| Activity of plasma nonspecific esterase | from 30 minutes before the surgery until to the time after stop infusion of remifentanil, , assessed up to about 2 hours | Determined by laboratory detection |
Countries
China
Outcome results
None listed