Advanced Cancer Requiring Palliative Radiation
Conditions
Brief summary
The objective of this trial is to assess the efficacy, acceptability, and scalability of diagnostic-CT-enabled planning, compared to conventional CT simulation planning.
Interventions
DIAGNOSTIC_TESTDiagnostic-CT-enabled Planning
Diagnostic-CT-enabled planning for patient receiving palliative radiation treatment to bone, soft tissue and lung disease
DIAGNOSTIC_TESTStandard of Care
Patients will be booked for CT simulation and treatment as per the local institution's standard practice
Sponsors
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age 18 years or older * Able to provide informed consent * Patient has consented to PRT to bone/soft tissue metastases or primary targets in the thorax, abdomen, or pelvis and RO will use simple planning techniques (i.e. parallel-opposed pair or direct field beam arrangement) * Patient will be scheduled for same-day simulation and treatment (if randomized to Arm 1) * Patient has a pre-existing and recent (i.e. within 4 weeks of time of enrollment) diagnostic CT or CT-fused scan with full visualization of the region-of-interest which has been acquired from an approved diagnostic scanner * Patient positioning scan is deemed acceptable and reproducible (e.g., patient is lying supine and relatively flat, there is no/minimal motion blur, ect.) * Intravenous (IV)/oral contrast in the region-of-interest is permitted as long as it does not create artifact which obscured the target volume (density override calculations may be required)
Exclusion criteria
* Any contraindication to receiving radiation * Oncologic emergencies and/or on-call cases * Pregnant or lactating women * Cases requiring composite dosimetric planning to account for previous radiotherapy or extended distance set-up
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Time in Centre (TIC) on Treatment Day | 1 Treatment Day | This is defined as the total time in hours spent at the cancer centre from the scheduled CT simulation (Arrm 1) or treatment delivery (Arm 2) appointment until beam delivery completion. |
Countries
Canada
Contacts
Primary ContactDavid Palma, MD
Backup ContactMelissa O'Neil
Outcome results
None listed