Effect of Different Ultrasound Doses on Median Nerve Conduction Parameters

Effect of Non-thermal Parameters of Ultrasound on Median Motor Nerve Conduction Velocity.

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05233488

Enrollment

120

Registered

2022-02-10

Start date

2022-02-12

Completion date

2023-12-10

Last updated

2023-09-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Entrapment Neuropathies

Keywords

Pulsed Ultrasound, Nerve conduction parameters.

Brief summary

The current study investigates the effect of different doses of pulses ultrasound therapy on different nerve conduction parameters of the median nerve in healthy volunteering subjects.

Detailed description

In the current study, we apply pulsed ultrasound therapy on median nerves of healthy volunteer subjects, at 1 W/cm2 10% duty cycle, 3 W/cm2 10% duty cycle, 1 W/cm2 50% duty cycle, and 3 w/cm2 50% duty cycle. Parameters of median nerve conduction study, Latency, amplitude, area, duration and forearm NCV are recorded before and after application of ultrasound therapy.

Interventions

DEVICEPulsed Ultrasound Therapy

Ultrasound therapy is applied in the pulsed mode.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Caregiver)

Masking description

Participant applicator are blinded to the US dose used.

Intervention model description

Four groups; First group receives pulsed US 1 W/cm2 10% duty cycle. Second group receives pulsed US 1 W/cm2 50% duty cycle. Third group receives pulsed US 3 W/cm2 10% duty cycle. Fourth group receives pulsed US 3 W/cm2 50% duty cycle.

Eligibility

Sex/Gender

ALL

Age

18 Years to 24 Years

Healthy volunteers

Yes

Inclusion criteria

1. 120 hands of 60 subjects of both genders with age range 18: 24 years. 2. Subjects assigned will be apparently healthy subjects with no neurological or neuromuscular history affecting the upper limb.

Exclusion criteria

1. Peripheral polyneuropathy. 2. Diabetes mellitus. 3. Previous surgeries or median and/or ulnar nerve release. 4. Cervical radiculopathy. 5. Median or ulnar entrapment neuropathies. 6. Previous or current pregnancies.

Design outcomes

Primary

Measure	Time frame	Description
CMAP distal latency	Immediately after application	msecond
CMAP amplitude	Immediately after application	mV
CMAP duration	Immediately after application	msecond
Nerve conduction study	Immediately after application	m/sec.

Countries

Egypt

Contacts

Primary ContactAmr S Shalaby, Ph.D.

amr.saad@pt.cu.edu.eg00201147718803

Backup ContactMarwa MH Abousenna, M.Sc.

marwa_hany@hotmail.com00201153261600

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026