Human Sleep and Chronobiology
Conditions
Brief summary
The purpose of this project is to study the influence of light on sleep, wakefulness, EEG activity and cognitive performances.
Interventions
DEVICEpolychromatic light
Application of polychromatic light at different times of day
DEVICEred light
Application of red light at different times of day
DEVICEgreen light
Application of green light at different times of day
Sponsors
University Hospital, Strasbourg, France
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Male or female * Aged 18 to 40 years * With a hint of Bodymass index (BMI) between 17 and 30 kg.m - 2 * healthy subject determined by a clinical examination, a psychological interview, a blood test, a urine analysis * Subject with a score\<6 questionnaire PSQI (Sleep Questionnaire Pittsburgh) * Subject agreeing to maintain a regular sleep/wake rhythm during the study * Subject agreeing to refrain from caffeine, nicotine, alcohol, psychotropic drugs, cannabis or other drugs, during the study * Signed informed consent * Subjectaffiliated to a social protection scheme
Exclusion criteria
* somatic diseases: cardiovascular, respiratory, gastrointestinal, hematopoietic, Visual * immune system diseases * kidneys and urinary tract diseases * endocrine and metabolic diseases * neurological diseases * infectious diseases * thrombocytopenia or other malfunction of blood platelets * Subject with risk of thrombosis, including subject with a history of phlebitis, smoker under oral contraceptive... * Subject with an addiction to caffeine, nicotine, alcohol, psychotropic drugs, cannabis, or any other drug * Subject treatment contraindicated or inadvisable in combination with heparin * blood donation in the previous 3 months before the inclusion * Participation in other clinical trials * Work by shifts in the year preceding the inclusion * Trans-meridian travel (\> 2 time zones) in the month previous the inclusion * Impossibility to give enlightened information (subject in an emergency situation, understanding difficulties,...) * Subject under safeguard of justice * Subject under tutorship or curatorship * Pregnancy (women of childbearing age) * Breastfeeding * Diet incompatible with the study's snack choices
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cognitive performances assessed using N-back tasks | up to 56 hours | N-Back-Task 1, 2, 3 |
| Cognitive performances assessed using Psychomotor Vigilance task (PVT) | up to 56 hours | Psychomotor Vigilance task (PVT) |
| Cognitive performances assessed using Paced Visual Serial Addition Task (PVSAT) | up to 56 hours | Paced Visual Serial Addition Task (PVSAT) |
Countries
France
Contacts
Primary ContactPatrice BOURGIN, MD
Outcome results
None listed