Type 2 Diabetes
Conditions
Keywords
Antioxidant, Obesity, Pomegranate peel, Oxidation, Type 2 Diabetes
Brief summary
The aim of this study is to evaluate the effects of the consumption of bread produced with the addition of pomegranate peels, which has a high antioxidant content, on blood glucose and lipid parameters, and some oxidant-antioxidant enzymes and lipid peroxidation in individuals with type 2 diabetes.
Detailed description
Between 01.02.2022 and 30.05.2022 with Specialist Dr. Emel SENOL's approval, by Specialist Dr. Akkız Zuhal ÖZTAŞ The study will be conducted with 30 volunteers who present to the City Hospital Internal Medicine Polyclinic in Mersin.
Interventions
DIETARY_SUPPLEMENTPomegranate Peel
Standard bread and test breads (with added pomegranate peel) to be used in the study will be produced by Asst. Prof. Özlem ÖZPAK AKKUŞ in the Nutrition Principles Laboratory of Toros University. For standard bread, 900 ml of water, 42 fresh yeast, 12 g of salt and 12 g of sunflower oil will be added to 1000 g of sifted whole wheat flour and the prepared bread mixture will be divided into 40 equal parts. To make bread with pomegranate peel added, 1000 g of sifted whole wheat flour, 20 g of pomegranate peel powder, 914 ml of water, 42 g of fresh yeast, 12 g of salt and 12 g of sunflower oil will be added and the prepared bread mixture is divided into 40 equal parts with 500 mg of pomegranate peel powder in each piece).
Sponsors
Toros University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
DOUBLE (Subject, Caregiver)
Masking description
Participants will not know which type of bread to eat.
Intervention model description
The study will conduct by using a prospective randomized double-blind clinical trial model.
Eligibility
Sex/Gender
ALL
Age
19 Years to 64 Years
Healthy volunteers
No
Inclusion criteria
* Being diagnosed with type 2 diabetes for at least 5 years, * Using only oral antidiabetic * With a Body Mass Index (BMI) value ≥ 25.0 kg/m2, * Signing the Informed Voluntary Consent Form, * Being in an age range of 19-64 years.
Exclusion criteria
* Having kidney, liver, and inflammatory diseases, * Being on insulin therapy, * Using prescription drugs and/or fiber supplements, * Taking vitamin and mineral supplements, * Being pregnant/lactating, * Consuming excessive alcohol (\>2 drinks/day), * Being in the menstrual period, * Receiving gluten enteropathy, * Having allergy against pomegranate. * In addition, individuals with Covid-19-related condition during the study process will be excluded from the study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Anthropometric Measurements - Hip Circumference | First day at the beginning of the study | Examination of between group differences regarding hip circumference in centimeters |
| Biochemical Blood Parameters | First day at the beginning of the study | Examination of between group differences regarding lipid profile |
| Anthropometric Measurements - Weight | First day at the beginning of the study | Examination of between group differences regarding weight in kilogram |
| Anthropometric Measurements - Height | First day at the beginning of the study | Examination of between group differences regarding height in meter |
| Anthropometric Measurements - Body Mass Index | First day at the beginning of the study | Examination of between group differences regarding body mass index (BMI = weight in kilogram / height in meter 2) |
| Anthropometric Measurements - Waist Circumference | First day at the beginning of the study | Examination of between group differences regarding waist circumference in centimeters |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Biochemical Blood Parameters | Eight weeks after the start of the study | Comparison of between group differences regarding lipid profile |
| Anthropometric Measurements - Weight | Eight weeks after the start of the study | Examination of between group differences regarding weight in kilogram |
| Anthropometric Measurements - Height | Eight weeks after the start of the study | Examination of between group differences regarding height in meter |
| Anthropometric Measurements - Body Mass Index | Eight weeks after the start of the study | Examination of between group differences regarding body mass index (BMI = weight in kilogram / height in meter 2) |
| Anthropometric Measurements - Waist Circumference | Eight weeks after the start of the study | Examination of between group differences regarding waist circumference in centimeters |
| Anthropometric Measurements - Hip Circumference | Eight weeks after the start of the study | Examination of between group differences regarding hip circumference in centimeters |
Countries
Turkey (Türkiye)
Outcome results
None listed