Colonization, Asymptomatic
Conditions
Keywords
colonization, microbiota, fungi, immunocompromised
Brief summary
Fungal colonization causes opportunistic infection that may manifest when the host's immune status deteriorates. The purpose of this study was to determine the prevalence of fungal colonization in immunocompromised subjects compared to healthy controls.
Interventions
OTHERnasal irrigation
regular saline nasal rinse
Sponsors
Taichung Veterans General Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
Yes
Inclusion criteria
* Immunocompromised subjects included those who had known risk factors for fungal infection, including malignant diseases, diabetes, autoimmune disorders, renal or hepatic insufficiency, organ transplantation, or use of immunosuppressants * Healthy volunteers had neither sinonasal symptoms nor nasal endoscopic inflammation.
Exclusion criteria
* Patients were excluded if they were under 20 years old, were receiving antifungal medication, or were pregnant.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| nasal lavage pooled fungal microbiota | 1 month |
Secondary
| Measure | Time frame |
|---|---|
| nasal lavage aspergillus qPCR | 1 month |
Countries
Taiwan
Outcome results
None listed