Infected Non Union and Delayed Union in Fractures of Both Long and Short Bones
Conditions
Brief summary
* Diagnosis of infection based on elevated serum markers of infection (ESR, CRP), discharging sinus, preoperative radiographs suggestive of bone infection and radiological findings . \[6\] * infected nonunion mean the bone has previous fracture , the bone not healed may be one of the reasons it didn't heal because there is sub-acute infection , there is low grade colonization into the bone or around the wound preventing the bone from healing , it different from infected fracture which occur fairly acutely. \[6, 7\] * Infected nonunion treated with systemic antibiotics alone, without using local antibiotic delivery systems associated with higher recurrence and reoperation rates. \[7\] * This led to the development and use of medical-grade calcium sulfate (CS), CS facilitates osseous healing in an osteoconductive fashion by filling the bone void and preventing fibrous tissue
Interventions
debridement of infected non united fractures and placement of local calcium sulfate loaded by antibiotic then follow up at regular intervals
Sponsors
Study design
Eligibility
Inclusion criteria
* Patient at any age and of any sex with infected non united fracture of long or short bones
Exclusion criteria
* Presence of previous vascular injury or pathological fracture * Refusal to participate * Inability to provide informed consent * Allergy or sensitivity to vancomycin or tobramycin * Patient with impaired renal function * Patient with hypercalcemia
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Non union scoring system | one year | Non-Union Scoring System (NUSS) aims to classify non-unions according to their severity and relate them to four treatment categories. |
| Karlström-Olerud physical function scale | one year | Karlström-Olerud physical function scale is a scale to assess physical functional outcome postoperative. |
Countries
Egypt