Intraoperative Blood Loss, Meningioma, Tranexamic Acid
Conditions
Brief summary
Intra-operative blood loss of huge meningioma resection patients on average was over 1000ml. Intra-operative massive hemorrhage was associated with longer hospital of stay, higher expense, and higher mortality. Previous studies indicated intra-operative tranexamic acid infusion would decrease blood loss for cardiac, trauma and obstetric procedures. However, limited researches focusing on the effect of tranexamic acid in neurosurgery population, with heterogenous pathologies. The purpose of this study was to investigate the effect of tranexamic acid on intra-operative blood loss in patients undergoing huge meningioma resection.
Interventions
DRUGContinous infusion
The 20mg/kg tranexamic acid will be diluted into a 50ml syringe and infused followed by 5mg/kg/h tranexamic acid infusion.
DRUGSingle infusion
The 20mg/kg tranexamic acid will be diluted into a 50ml syringe and infused followed by same volume of 0.9% saline.
DRUGPlacebo
The 0.9% saline is administered with the same volume at the same speed as the other group.
Sponsors
Beijing Tiantan Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Patients undergoing elective supratentorial meningioma resection with estimated tumor diameter \>5cm on brain image. * Age between 18-65 years. * American Society of Anaesthesiologist (ASA) physical status Ⅰ to Ⅲ * Obtain written informed consent.
Exclusion criteria
* Allergic to tranexamic acid. * History of thrombotic disease. * History of chronic kidney disease * Receiving other anticoagulation or antiplatelet treatment. * Refuse to provide written informed consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Estimated intra-operative blood loss | During surgery | Estimated intra-operative blood loss is assessed as following formula:collected blood volume in the suction canister (mL) - the volume of flushing (mL) + the volume from gauze tampon (mL). |
Countries
China
Contacts
Primary ContactShu Li, M.D.
Outcome results
None listed